T cell lineages are defined by specialized functions and differential expression of surface antigens, cytokines and transcription factors. Conventional CD4+ and CD8+ T cells are the best studied of the T cell subsets, but ‘unconventional’ T cells have
Intestinal regulatory T cells (Tregcells) are distinct from those in other organs and function to maintain tolerance to harmless dietary antigens and commensal microorganisms. The unique features of these cells, as well as the signals involved in their d
Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells T cell developmentTCRγδ signal strengthmurine γδ T?cellsDespite a growing appreciation of γδ T cell contributions to numerous immune responses, the... Sumaria, Nital,Grandjean, Capucine L.,Silva-Santos,...
NOD FTOC produce more TNF-α than B6 FTOC during days 6–9 of culture, a time when negative selection of T cells is known to occur. Neutralization of this endogenous TNF-α production in NOD derived FTOC with soluble TNF receptor (sTNF R1) rescued insulin production in our in vitro T1DM...
Signaling lymphocytic-activation molecule F7 (SLAMF7) is a promising target for CAR T cell therapies of the plasma cell malignancy multiple myeloma (MM) because SLAMF7 is expressed by MM but not normal nonhematopoietic cells. We designed CARs targeting SLAMF7. We transduced human T cells with ...
stem cells and development 这个期刊，可以带带我吗，真的弄不太懂 发自小木虫IOS客户端 ...
Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells - ScienceDirect Objective: We sought to determine the efficacy of intrathymic adeno-associated virus (AAV) serotypes to transduce thymocyte subsets and correct the T-cell...
Development and function of T cells in T cell antigen receptor/CD3 ζ knockout mice reconstituted with FcRIγ Engagement of α -β T cell receptors (TCRs) induces many events in the T cells bearing them. The proteins that transduce these signals to the inside of ce... Liu, C.-P.,Lin...
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation. Mol. Cell 10, 1083–1096 (2002). CAS PubMed Google Scholar Zou, Y.R. et al. Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage. Nat. Genet. 29, 332–336 (2001). CAS ...
of over 500,000 single cells from 15 individuals with AML and tissue from 9 healthy individuals for prediction of target antigens that are expressed on malignant cells but lacking on healthy cells, including T cells. Aided by this high-resolution, single-cell expression approach, we ...