Antibody drug conjugates (ADCs) are a rapidly growing class of targeted cancer drugs in which a highly toxic small molecule (payload) is conjugated to a tumor-selective antibody. Over the past two decades, a total of 11 ADCs have been approved by the FDA in the United States; including: ...
The use of monoclonal antibodies as therapeutic vector was hypothesized by Paul Ehrlich within the concept of the “Magic Bullet” [1]. Remarkable improvements in biology and chemistry led to the development of antibody–drug conjugates (ADCs), a new generation of biotherapeutics that combines the ...
Advances in our understanding of cancer biology have enabled drug development to progress towards better targeted therapies that are both more effective and safer owing to their lack of off-target toxicities. In this regard, antibody–drug conjugates (ADCs), which have the potential to combine the...
After determining that ICAM1 has the ability to efficiently mediate antibody internalization, we constructed two ICAM1 antibody-drug conjugates (ADCs) by conjugating ICAM1 antibodies to different cytotoxic payloads through cleavable chemical linkers. The efficacies of two ICAM1 ADCs have been evaluated ...
The development of antibody–drug conjugates (ADCs) represents a novel approach to improving the therapeutic index of cytotoxic agents by selectively delivering potent cytotoxic drugs to tumors while minimizing exposure and toxicity to normal tissues. The past decade has seen a significant progress in ...
. Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1). 2015:, 213-230. /Sandhya, GirishGail D., Lewis PhillipsFredric S., JacobsonJagath R., JunutulaEllie, Guardino. Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1). 2015:, 213-...
Antibody-drug conjugates (ADCs) are a new implementation of an old idea: using antibodies to deliver toxic payloads directly to tumor cells. The antibody serves as a molecular “global positioning system” to locate tumor cells; the payload is a highly toxic agent connected to the antibody thro...
我们可以谈事 [translate] aOh,yes.Everything was excellent.Where did you go,Xiang Hua? 噢,是。一切是优秀的。您何处去, Xiang华? [translate] aAnalytical Challenges in the Development of Assays to Support Antibody Drug Conjugates 分析挑战在支持抗体药物共轭的分析用试样的发展 [translate] ...
Antibody-drug conjugates (ADC) selectively deliver a cytotoxic drug to cells expressing an accessible antigenic target. Here, we have appended monomethyl auristatin E (MMAE) to an antibody recognizing the SLC34A2 gene product NaPi2b, the type II sodium-phosphate cotransporter, which is highly expres...
Antibody-Drug Conjugates (ADCs) developed as a targeted treatment approach to deliver toxins directly to cancer cells are one of the fastest growing classes of oncology therapeutics, with eight ADCs and two immunotoxins approved for clinical use. However, selection of an optimum target and payload ...