稳定性:DARPins在热力学、热和储存稳定性方面表现出色,这种稳定性也是产生多特异性蛋白质的良好基础。 渗透性强:由于DARPins的分子量较小,它们具有更强的组织渗透性,能够更容易地进入肿瘤内部发挥作用。 安全性与低免疫原性:DARPins具有较高的安全性和较低的免疫原性,减少了治疗过程中的副作用风险。 多靶向性:DARP...
Designed ankyrin repeat proteins (DARPins) from research to therapy . Methods Enzymol 503 , 101–134 (2012).Tamaskovic R, Simon M, Stefan N, Schwill M, Pluckthun A 2012. Designed ankyrin repeat proteins (DARPins) from research to therapy . Methods Enzymol 503 :101–134. doi:.10.1016/B...
Designed ankyrin repeat proteins (DARPins) have been developed into a robust and versatile scaffold for binding proteins. High-affinity binders are routinely selected by ribosome display and phage display. DARPins have entered clinical trials and have found numerous uses in research, due to their hi...
Designed ankyrin-repeat proteins (DARPins) are potential antibody alternatives and have been engineered by others to specifically bind a variety of protein targets including maltose-binding protein (MBP). DARPin's hence serves as an excellent platform to study biomolecular interactions and develop ...
As a useful alternative Designed Ankyrin Repeat Proteins (DARPins) have been developed [7,8,9]. These designed proteins use the Ankyrin repeat fold consisting of two antiparallel helices, connected by a loop to the next unit. Three to five of these repeat units can be combined into a ...
access to life-changing radiopharmaceuticals, andAthebio AG(“Athebio”), an innovation leader in the discovery and design of designed ankyrin repeat proteins (DARPins), today announced a collaboration and license agreement to develop and commercialize DARPin-targeted radioligands (“Radio-...
By assembly of the randomized repeat modules, complex libraries of designed ankyrin repeat proteins (DARPins) can be generated. The number of randomized repeat modules used determines the size of the final protein, and with increasing numbers of repeat modules, the interaction interface and the ...
ATHEBIO enables its partners to develop superior targeted therapeutics of advanced efficacy and safety and thereby increased probability of clinical success. ATHEBIO’s proprietary “plug & play” Athebody® platform is based on clinically validated designed anky...
Gut 2011;60:A110 doi:10.1136/gut.2011.239301.230 Posters Neoplasia and cancer pathogenesis Biologic anticancer activity of designed ankyrin repeat proteins (darpins) targeted against dnmt1 and conjugated to docetaxel leads to eradication of chemoresistant mutated squamous cell epsophageal cancer stem ...
Stumpp et al., “DARPins: A new generation of protein therapeutics”, Drug Discovery Today (2008) 13(15-16), p. 695-701. Theurillat et al., “Designed ankyrin repeat proteins: a novel tool for testing epidermal growth factor receptor 2 expression in breast cancer”, Modern Pathology (...