Baumann MJ, Stadler BM, Vogel M (2007) Potential applications of designed ankyrin repeat proteins in diagnostics and therapeutics. Exp Opin Med Diagn 1:409-421Baumann MJ, Stadler BM, Vogel M (2007) Potential applications of designed ankyrin repeat proteins in diagnostics and therapeutics. Exp ...
Designed ankyrin-repeat proteins (DARPins) are potential antibody alternatives and have been engineered by others to specifically bind a variety of protein targets including maltose-binding protein (MBP). DARPin's hence serves as an excellent platform to study biomolecular interactions and develop ...
Switzerland 1289 Designed ankyrin repeat proteins are a novel class of specific binding molecules, which display increased thermodynamic stability, smaller size and at least equal target affinity compared to immunoglobulins, making them potentially powerful tools in diagnostic pathology and therapeutic oncology...
国省代号: CH 被引量: 1 摘要: New designed ankyrin repeat proteins with binding specificity for PDGF-BB are described, as well as nucleic acids encoding such PDGF binding proteins, pharmaceutical compositions comprising such proteins and the use of such proteins in the treatment of diseases.收...
--POINT Biopharma Global Inc., a company accelerating the discovery, development, and global access to life-changing radiopharmaceuticals, and Athebio AG, an innovation leader in the discovery and design of designed ankyrin repeat proteins, today announc
Designed ankyrin repeat proteins (DARPins) are a novel class of binding proteins that bind their target protein with high affinity and specificity and have very favorable expression and stability properties. We describe here the in vitro selection of DARPins against human epidermal growth factor ...
“POINT”), a company accelerating the discovery, development, and global access to life-changing radiopharmaceuticals, andAthebio AG(“Athebio”), an innovation leader in the discovery and design of designed ankyrin repeat proteins (DARPins), today announced a...
Biologic anticancer activity of designed ankyrin repeat proteins (darpins) targeted against dnmt1 and conjugated to docetaxel leads to eradication of chemoresistant mutated squamous cell epsophageal cancer stem cells J Giannios *1, S Delis2, V Barbunis3 1Translational Cancer Medicine, Erasinio ...
We show here that with very small high-affinity proteins such as designed ankyrin repeat proteins (DARPins), these limits can be overcome. We have systematically investigated the influence of molecular mass and affinity on tumor accumulation with DARPins with specificity for HER2 in SK-OV-3.ip ...
M. On the binding affinity of macromolecular interactions: daring to ask why proteins interact. J R Soc Interface 10, 20120835 (2013). 18. Plückthun, A. Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy. Annu Rev Pharmacol Toxicol 55, 489–...