Descartes-08是一种靶向B细胞成熟抗原(BCMA)的自体mRNA工程化嵌合抗原受体T细胞(mRNA CAR-T)疗法。与传统的基于DNA的CAR-T细胞疗法相比,mRNA CAR-T细胞疗法的给药设计不需要预处理化疗,而且据观察具有可预测和可控制的药代动力学,可以进行门诊给药,并避免了基因整合和癌症转化的风险。 临床数据 在这项IIb期双盲、...
Descartes-08是一种靶向B细胞成熟抗原(BCMA)的自体mRNA工程化嵌合抗原受体T细胞(mRNA CAR-T)疗法。与传统的基于DNA的CAR-T细胞疗法相比,mRNA CAR-T细胞疗法的给药设计不需要预处理化疗,而且据观察具有可预测和可控制的药代动力学,可以进行门诊给药,并避免了基因整合和癌症转化的风险。 临床数据 在这项IIb期双盲、...
Descartes-08是一种靶向B细胞成熟抗原(BCMA)的自体mRNA工程化嵌合抗原受体T细胞(mRNA CAR-T)疗法。与传统的基于DNA的CAR-T细胞疗法相比,mRNA CAR-T细胞疗法的给药设计不需要预处理化疗,而且据观察具有可预测和可控制的药代动力学,可以...
力相关的临床缓解,以及持续的自身抗体的清除。
The FDA granted a Special Protocol Assessment (SPA) agreement on the phase 3 trial design for Descartes-08, indicating a clear regulatory pathway toward potential approval. The Phase 3 AURORA trial is set to assess Descartes-08's effectiveness in myasthenia gravis, which could...
“Supported by compelling Phase 2b results where we observed deep and durable improvements in patients with MG, we firmly believe that Descartes-08 has the potential to serve as a meaningful new therapy that can be delivered in the convenient outpatient set...
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"A Lingering Whiff of Descartes in the Air": From Theoretical Ideas to the Messiness of Clinical Participation: Commentary on Paper by the Boston Change Pr... From a perspective in recognition of my unconscious attachment to their theoretical conceptualizations as well as intrinsic blind spots to ...
The Allegory Of The Cave By Plato And Rene Descartes Plato, being a Socratic apprentice, followed and transcribed the experiences Socrates had in his teachings and search of understanding. In Plato’s first work, The Allegory of the Cave, Socrates forms the understanding between appearance vs. re...
How are we to understand Descartes' view on the power and scope of reason? According to a common view, Descartes traffics in what I call 'theocentric rationalism.' Theocentric rationalism holds that human reason resembles divine reason, according to which God created the world. A hallmark of ...