dengue virusdrug discoveryflavivirusinhibitorDengue fever is caused by infections with dengue virus, the most prevalent mosquito-borne viral pathogen in humans. There are no drugs available to treat dengue virus infection. Here, we discuss the strategies and challenges to develop dengue drugs. ...
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including 96 million symptomatic illnesses.355Dengue is caused by any of four antigenically distinct virusserotypes(DEN-1, -2, -3, -4) of the genusFlavivirus.Infection with one of these serotypes is not cross protective. Infection withdengue virusesproduces a spectrum of clinical illness that ...
Dengue is a spectrum of disease caused by one of the four serotypes of the most prevalent arthropod-borne virus that affect humans today, dengue viruses (DENV). The four DENV serotypes (DENV-1 to -4) belong to the Flaviviridae family and circulate concomitantly in different regions of the ...
The DENV-1 strain isolated during the 2006 epidemic is closely related to the strains isolated during the 2001 epidemic (Figure 1B). It suggested that DENV probably circulated in local and caused the epidemics of 2001 and 2006. Moreover, there were several clear divisions within the Chinese ...
This refers to a secondary dengue virus (DENV) infection with the same serotype that caused the primary infection. For example, DENV1 infection followed by a secondary DENV1 infection. T effector memory RA cells (TEMRA cells). Terminally differentiated antigen-specific memory T cells that re-ex...
(DHF), and if neglected or undetected, it can lead to Dengue shock syndrome (DSS) [18,19,20]. Dengue has evolved into a serious, potentially fatal consequence for people, as there is currently no vaccine that can effectively reduce the severity of the disease caused by all serotypes, ...
Dengue is one of the most important mosquito-borne viral infections caused by single-stranded RNA virus that are transmitted by the Aedes aegypti and Aedes albopictus mosquito species. Dengue is endemic in over 140 countries in Asia, the USA, the Eastern
Characterization of the encephalitis caused by DENV2 shows that although DENV2 infects neurons, the virus induces extensive astrogliosis and microgliosis as well as macrophage and NK cell infiltration. The cellular infiltration and inflammation are associated with increased mRNA levels of genes associate...
Dengue feveris caused by a mosquito-transmitted arboviral infection in tropical and subtropical zones of the world, including South Asia. The vector is bothAedes aegypyti andA albopictusmosquitos.10Children may present with high fever, headache, chills, anorexia, nausea, vomiting, myalgias, and ar...