Journal of NeuroimmunologyZhou L, Huang Y, Li H, Fan J, Zhangbao J, Yu H, Li Y, Lu J, Zhao C, Lu C, et al. MOG-antibody associated demyelinating disease of the CNS: a clinical and pathological study in Chinese Han patients. J Neuroimmunol. 2017;305:19-28....
ADEM is an acute monophasic inflammatory demyelinating disease of the CNS. Although it can occur at any age, it mainly affects children and young adults (Wingerchuk, 2006). The disease may be preceded by an infectious disease or, less frequently, by vaccination (Wingerchuk, 2003, Karussis and...
demyelinating plaques has made this technique the most important paraclinical tool in current use, not only for the early and accurate diagnosis of MS, but also for under- standing the natural history of the disease and monitoring and predicting the efficacy of disease-modifying treatments [4]. ...
Demyelinating diseasesExperimental models of diseasePathogenesisAn inability to remove excess cholesterol after myelin damage could underlie the defective remyelination and recovery observed in old age, according to a new study published in Science . Investigators found that expression of cholesterol ...
Demyelinating Disease Types Classification of the demyelinating diseases is done on the basis of whether they are affecting the nerves of the central nervous system or of the peripheral nervous system. Central Nervous System Diseases resulting from demyelination of the central nervous system (CNS) nerve...
nature publishing group ARTICLES A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease J Ochoa-Repáraz1, DW Mielcarz2, Y Wang2, S Begum-Haque1, S Dasgupta3, DL Kasper3 and LH Kasper1 The intestinal microbiome may have a critical roll in ...
The pathological axis, consisting of angiotensin II (A1-8), angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT1R), is upregulated in many CNS diseases, including multiple sclerosis (MS). MS is an autoimmune and neurodegenerative disease of the CNS characterized by ...
acquired disease of CNS myelin how would you describe the demyelination of MS? relapsing remitting course of demyelination is disseminated, but has a predilection for periventricular white matter •Over time, demyelinating lesions and axonal loss accumulate; progressive atrophy and corresponding progressive...
14、te or subacute demyelinating disease involved optic N and spinal cord at the same time.2.Etiology And Pathogenesis :与遗传素质和种族差异有关。西方-脑干;东方-视神经和脊髓;25%MS突发球后视神经炎;多方研究证实白种人对MS易感;非白种人对NMO易感。3.Pathology:Demyelination,plaque of sclerosis, in...
demyelinating disease 神经纤维的髓鞘脱失而神经细胞相对甚少受累的一类疾病。病因不同,临床表现各异,但具有共同的病理特征。这类疾病分为两组,即髓鞘形成障碍型和髓鞘破坏型。髓鞘形成障碍型脱髓鞘疾病是遗传代谢缺陷引起的髓鞘形成障碍,主要包括髓鞘磷脂代谢异常引起的脑白质营养不良,如异染性白质脑病、脑白质海绵样...