Engineered virus-like particles for effificient in vivo delivery of therapeutic proteins 半胱氨酸碱基编辑器(CBEs)和腺嘌呤碱基编辑器(ABEs)可以共同应用于更正绝大多数已知的由单核苷酸突变导致的疾病,并在小鼠和非人类灵长类动物中进行了测试,证实体内碱基编辑具有成为一种治疗策略的潜力。 体内碱基编辑技术的广泛...
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Commonly, protein-based drugs are referred as therapeutic proteins. However, the term was first used to the biologics that are genetically engineered version of naturally occurring human proteins. Therapeutic proteins are large molecules consisting of long chain amino acids with multi-folded structural ...
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins Cell, 185 (2022), pp. 250-265.e16, 10.1016/j.cell.2021.12.021 View PDFView articleView in ScopusGoogle Scholar Bareford and Swaan, 2007 L.M. Bareford, P.W. Swaan Endocytic mechanisms for targeted drug...
Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes. Therapeutic alteration of gene expression in vivo can be achieved by delivering nucleic acids (e.g., mRNA, siRNA) using nanoparticles. Recent progress in m... Nuphar,Veiga,Meir,... - 《Nature Communications》 ...
The direct delivery of functional proteins into the cell cytosol is a key issue for protein therapy, with many current strategies resulting in endosomal entrapment. Protein delivery to the cytosol is challenging due to the high molecular weight and the polarity of therapeutic proteins. Here we revie...
(e.g., delivering insulin for diabetes). However, the size and stability of proteins limit their utility towards many potential disease targets [7]. Thus, true realization of the therapeutic potential of personalized genomics requires treatments beyond those offered by current small-molecule and ...
biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, ...
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