Most deleterious mutations have very slight effects on total fitness, and it has become clear that below a certain fitness effect threshold, such low-impact mutations fail to respond to natural selection. The existence of such a selection threshold suggests that many low-impact deleterious mutations...
13), whereas the heterozygous-mutation burden markedly increased, by 96% (P = 8.1 × 10−7, Fig. 5c), despite the decreased genetic diversity in cultivated cassava (π = 0.0036) compared with progenitors (π = 0.0051). In addition, we also compared the observed and mutation burdens ...
Synonyms for deleterious in Free Thesaurus. Antonyms for deleterious. 20 synonyms for deleterious: harmful, bad, damaging, destructive, detrimental, hurtful, pernicious, ruinous, prejudicial, injurious, bad, detrimental, evil... What are synonyms for de
029 nonsynonymous deleterious SNPs defined by SIFT score <0.05 with the correction of reference bias (Supplementary Fig.12)49. We observed similar patterns in the mutation load among subgroups to those of GERP-based estimation (Supplementary Fig.13). However, even with the correction, an ~...
Heritably transferred genome mutations extending phenotypic variability together with natural selection (alternatively with genetic drift, draft, stability
A theoretical analysis was carried out on the mutation load observed in long-maintained inbred lines from two experiments with Drosophila and mice. The rate of decline in fitness and its sampling distribution were predicted for both experiments using Mon
Define deleteriousness. deleteriousness synonyms, deleteriousness pronunciation, deleteriousness translation, English dictionary definition of deleteriousness. adj. Having a harmful effect; injurious: the deleterious effects of smoking. del′e·te′ri·o
Molecular cloning of XS2 identified a deleterious mutation in CATION CALCIUM EXCHANGER 4 (CCX4). Phytohormone measurement and expression analysis revealed that... F Ushio,K Ezaki,G Horiguchi,... - 《Plos Genetics》 被引量: 0发表: 2020年 Structural and functional analysis of KIT gene encoding ...
Deleterious mutation and genetic recombination. Nee - 《Nature》 被引量: 0发表: 1988年 The Effect of Deleterious Mutations on Neutral Molecular Variation Selection against deleterious alleles maintained by mutation may cause a reduction in the amount of genetic variability at linked neutral sites. ...
No signal of deleterious mutation accumulation in conserved gene sequences of extant asexual hexapodsLoss of sex and recombination is generally assumed to impede the effectiveness of purifying selection and to result in the accumulation of slightly deleterious mutations. Empirical evidence for this has ...