Under this scenario, mutations that reduce health, and thus nonsexual fitness, may also be deleterious with respect to reproductive success, meaning that sexual selection may contribute to the purging of deleterious alleles. We tested this hypothesis directly by subjecting replicate Drosophila ...
What are deleterious mutations? Listen to pronunciation. (DEH-leh-TEER-ee-us myoo-TAY-shun)A genetic alteration that increases an individual's susceptibility or predisposition to a certain disease or disorder. When such a variant (or mutation) is inherited, development of symptoms is more likely,...
esculentus mutation-free individuals in the initial population, and with any value for δ e and σ, the lethal deleterious mutation diffuses slowly. This slow diffusion is not able to prevent the production of a sufficient number of viable P. ridibundus females, which leads to the collapse of...
The Hardy-Weinberg equilibrium represents an idealized, evolution-free population in which the allele frequencies and genotype frequencies will not change over time. In order for this to happen, five conditions must be met: 1) there must be no mutation; 2 ...
Unless otherwise specified, the Eker rat which has a mutation in the tuberous sclerous gene (Tsc-2) was utilized in the studies described herein. One of ordinary skill in the art is aware of a variety of other laboratory rat or mouse strains with increased propensity for tumor formation. ...
where 0 indicates the least reliable while a 10 indicates the most reliable result. The DDG value measures the energy changes between a folded and unfolded structure. When the DDG value is higher than zero, the mutation is said to be able to increase the protein stability whereas a negative ...