Institute for Genomic BiologyProceedings of the National Academy of Sciences of the United States of AmericaNowick K, Gernat T, Almaas E, Stubbs L. 2009. Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain. Proc Natl Acad Sci ...
Transcription factors mediate the regulation of genes through context-specific interactions with enhancers and promoters20. To identify transcription factors controlling the temporally distinct changes in chromatin accessibility, we analyzed the DNA sequence within each cluster of accessible regions to find dif...
All multicellular organisms rely on differential gene transcription regulated by genomic enhancers, which function through cofactors that are recruited by transcription factors1,2. Emerging evidence suggests that not all cofactors are required at all enhancers3,4,5, yet whether these observations reflect ...
Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis The CBF cold response pathway has a prominent role in cold acclimation. The pathway includes action of three transcription factors, CBF1, 2 and 3 (also kno... JT Vogel,DG Zarka,HA...
Bifurcation dynamics in lineage-commitment in bipotent progenitor cells Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which r... H Sui,YP Guo,G May,... - 《Developmental Biology》 被引量: 626...
Transcription FactorsNeurotransmitter AgentsImmediate-Early ProteinsNerve Tissue ProteinsIntermittent exposure to addictive drugs causes long-lasting changes in responsiveness to these substances due to persistent molecular and cellular alterations within the meso-corticolimbic system. In this report, we studied ...
Formative pluripotency: The executive phase in a developmental continuum 2017, Development (Cambridge) A decade of transcription factor-mediated reprogramming to pluripotency 2016, Nature Reviews Molecular Cell Biology Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state 2015, Nature ...
Snail and Zeb transcription factors induce epithelial-to-mesenchymal transition (EMT) in embryonic and adult tissues by direct repression of E-cadherin transcription. The repression of E-cadherin transcription by the EMT inducers Snail1 and Zeb2 plays a fundamental role in defining embryonic territories...
In this review we discuss recent developments in FALC stromal cell biology and highlight key interactions that occur between FALC stroma and immune cells.Previous article in issue Next article in issue Sorry, something went wrong. Please try again and make sure cookies are enabled...
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease Parker C. Wilson Amit Verma Benjamin D. Humphreys Genome Biology(2024) Multi-scalar data integration decoding risk genes for chronic kidney disease ...