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High-resolution cryo-EM structures pinpoint vital residues and conformational changes in the proteasome 伪-subunit implicated in HbYX-dependent activation. Using point mutations, we simulated the HbYX-bound state, providing support for our mechanistic model. We discerned four main mechanistic elements ...
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease Parker C. Wilson Amit Verma Benjamin D. Humphreys Genome Biology(2024) Multi-scalar data integration decoding risk genes for chronic kidney disease ...
In this report, we studied the expression profiles of 159 genes in the accumbens during exposure (14 days, 10 mg/kg s.c.) and drug-abstinence (3 weeks). We used real-time quantitative to monitor gene expression after establishing its sensitivity and resolution to resolve small changes in ...
It is likely these BACs lie distal to the break and are not represented in human 14q, however the resolution of metaphase FISH did not allow for a finer map location with respect to the 14q orthologous region. Figure 7 Map of Hsa14q32 and Meu 1q. (A) Map of M. eugenii 1q ...
2011, Seminars in Cell and Developmental Biology Citation Excerpt : Finally, from the microtubule, they are transported and trapped into the distal actin-rich regions of dendritic filaments [49,50]. Rab27A and the actin motor MyoVA [51], co-localize with melanosomes [52] with the help of...
However, the protein and RNA composition of the internal NM remains incompletely understood and there is a need to correct this deficiency with methods that not only identify proteins and RNAs, but also localize them in the structure at high resolution, especially in new super resolution methods ...
Reads were processed using DADA2 v1.6 to obtain error-corrected amplicon sequence variant representatives—analogous to operational taxonomic units with single-nucleotide resolution (sOTUs) [38]. sOTUs were annotated with genus-level taxonomy using the RDP Naïve Bayesian Classifier [39] as implemented...
Transcriptome profiling at single-cell resolution has become a common practice for dissection of cell heterogeneity in complex tissues15,16. Single-cell transcriptome profiling based on the SMART-seq method generates RNA-seq reads with coverage of full-length transcripts, rather than just the 3’ reg...
Three transitions were acquired for each target analyte, the cycle time set to 0.8 s, Q1 resolution to 0.7 full-width at half-maximum, Q2 resolution at 1.2 full-width at half-maximum, and collision-induced dissociation gas at 1.5 mTorr. Data were uploaded into Skyline-Daily v.22.2....