Previous proteomic studies of sporadic AD CSF have revealed multiple proteins that are altered in later stages of the disease when individuals are cognitively impaired, and these proteins have been validated in multiple cohorts9,15,16,17. Based on these findings in late-onset AD (LOAD), we crea...
Said another way, a Seaway-size vessel can carry an equal cargo load 24% farther than rail and 531% farther than truck. For the post-renewal scenario, the Seaway- size fleet will be able to move cargo 74% farther (or is 74% more efficient) than rail and 704% farther (or is 704%...
(i) enrichment for BRCA signature with prevalent defects in the homologous recombination pathway; (ii) dominant T>G mutational pattern associated with a high mutational load and neoantigen burden; and (iii) C>A/T mutational pattern with evidence of an aging imprint. These subtypes could be ...
t.) To load; to burden. Oneration (n.) The act of loading. Onerous (a.) Burdensome; oppressive. Onerously (adv.) In an onerous manner. Ones (adv.) Once. Oneself (pron.) A reflexive form of the indefinite pronoun one. Commonly writen as two words, one's self. One-sided (a.)...
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apolipoprotein E (APOE) [96,99,100]. However, the effect of Trem2 on Aβ pathology has been inconsistent. Indeed, some studies using Trem2-/- mice have found no change in total plaque load [101,102], while other studies have found an increase [89,103] or even a decrease in load ...
such peptide markers may reflect bacterial actions more than the presence of bacteriaper se, which from a physiological point of view should correlate better to overall bacterial load and actions, and ultimately also, the clinical status of a particular wound. Hypothetically, combining the use of ...
This phase of morphogenesis presents a new challenge because the resting length of the septum is unknown, as it is first formed within the confine of the load-bearing wall of the mother cell and therefore does not experience any deformation until the daughter cells have separated. However, we ...
(right). Arrowheads, KIT-positive cells inPramef12Nulltestes. Scale bar, 50 μm.cQuantitative real-time RT-PCR ofKitmRNA abundance in P7Pramef12NullandPramef12Hettestes usingβ-actinas an internal load control and setting the abundance inPramef12Hettestis to 1. Mean ± s.d,n =...
and the goblet cell module linked to high mutation load andKRASmutation, withKRASmutation also correlating with the growth factor signaling module. In CRC the cell cycle module was not positively correlated withTP53mutation, but instead was linked to the broad swathe of highly mutated target genes...