VMS frequency data were anchored to PGI-C VMS data; the anchor level for meaningful within-patient change in PGI-C VMS was "moderately better."In the pooled population ( N =1022), the mean (standard deviation) estimated thresholds for a meaningful within-patient change in moderate-to-severe...
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n = 376), we identify coexpressed gene modules...
Integrative pharmacology is a discipline that builds an understanding of the inter-relationship between pharma- cokinetics (PK), the drug's time course for absorption, distribution, metabolism and excretion and pharmaco- dynamics (PD), the biological effect of a drug. In drug discovery, this ...