15. Induction of apoptosis was analyzed in three to five independent experiments. Quantification and statistical analysis Quantification and statistical analysis were performed using GraphPad Prism 10 and data are presented as mean ± standard deviation, as specified in the figure legends. Statistical...
Bars represent mean and standard deviation. (F) Same as in (E), but for the BRD3 locus. (G) MS heritability enrichment estimated for transcriptional pausing gene sets derived from Reactome (n = 200) and Gene Ontology (n = 100) using LDSR. The multi-test-corrected significance threshold ...
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn’s disease-like inflammation, lung fibrosis, and macrophage lipid accumulation in these patients remains enigmatic. The aim of this study i
Descriptive statistics (mean, standard deviation, and percentage) and analytical methods (t test, Chi square) were also used to analyze the data. Results After six months of treatment, the intervention group exhibited significantly lower levels of FBG (P < 0.001), 2 h-PG (P = ...
deviation below 0.1%. Before analysis, the excipients were dried at 75 °C for 30 min. All measurements were performed in triplicate. The helium pycnometer densities of the liquisolids were calculated from the values of the unloaded silica and the density of the liquid component. That is ...
institutional grants from Novo Nordisk, sanofi-aventis, Lilly, Boehringer Ingelheim, and Janssen; and payment for lectures or speakers bureaus from Novo Nordisk; sanofi-aventis; Lilly; Merck, Sharp & Dohme; Boehringer Ingelheim; AstraZeneca; Janssen; Mitsubishi Tanabe Pharma; and Takeda Pharmaceuticals...
impact of apabetalone therapy on CV risk, defined as a composite of major adverse cardiovascular events (MACE: CV death, non-fatal myocardial infarction [MI], or stroke) and hospitalization for heart failure (HHF) in two patient categories of FS that reflect the likelihood of underlying NAFLD...
The sodium-dependent glucose co-transporter-2 (SGLT2) is expressed in absorptive epithelia of the renal tubules. Remogliflozin etabonate (RE) is the prodrug of remogliflozin, the active entity that inhibits SGLT2. An inhibitor of this pathway would enhance urinary glucose excretion (UGE), an...
Oral dapagliflozin (Edistride®, Forxiga®) is approved in the EU at a dosage of 5 mg/day as an adjunct to insulin in adults with type 1 d
Pooled data from N = 3 separate experiments and Standard Deviation is shown. For inhibition assays (Figures 1C and S1), data was fit with a nonlinear regression with variable slope. Acknowledgments The authors would like to thank Adimab for the Anti-ActRIIB antibody as well as members of ...