Genome-wide expression profiling identified five biological BC subtypes36, namely luminal A/B, HER2-enriched, basal-like and normal breast-like, which differ by hormonal receptor status, proliferation, genomic instability, mutational signatures, treatment response and prognosis37,38,39,40,41. It has...
For decades, scientists have been focusing on PD genotype marker discovery. In the case ofLRRK2-G2019S mutation diagnosis alone, people are often found to either have the mutation in their genome without even experiencing PD (non-manifesting carrier/NMC) or do not have the mutation in their ...
For decades, scientists have been focusing on PD genotype marker discovery. In the case ofLRRK2-G2019S mutation diagnosis alone, people are often found to either have the mutation in their genome without even experiencing PD (non-manifesting carrier/NMC) or do not have the mutation in their ...
Figure 3. High-Density Map and Correlation Analysis (A) High-density map of all the RING1B SERs that are also bound by at least one PCGF. Each horizontal line represents a separate TSS, and the ± 5 kb region is shown for each protein, with the position of the TSS marked by the ...
Shaping fat distribution: new insights into the molecular determinants of depot- and sex-dependent adipose biology. Obesity (Silver Spring). 2015;23(7):1345–52. Article CAS Google Scholar Jensen MD. Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity ...
Losses of cyclin dependent kinase inhibitors, CDKN2A and CDKN2B, have been implicated as the tumor suppressor genes on chromosome 9p responsible for malignant meningioma phenotypes [10, 25]. We have focused on alterations between benign and malignant meningiomas since these histopathological groups are...
Caveolin-rich membrane domains were isolated on the basis of their low density and Triton X-100 insolubility as described under “Experimental Procedures.” These domains were boiled in Laemmli sample buffer under reducing conditions, resolved by preparative SDS-PAGE, and transferred to nitrocellulose....
Thus, a high proportion of CD105+ cells is dependent on SC (P < 0.001) in vitro (Fig. 2C). GBM‑derived CD105+ cells share similarities with mesenchymal stem cell‑like cells To phenotypically characterize CD105+ cells, we tested cell-type-specific markers ...
we optimized the use of an Agilent Bravo liquid handling device (Fig.S1B). Here, using an 8-channel head, cell solutions were transferred from the 96-well low attachment plate and distributed into a geltrex-coated Perkin Elmer Cell Carrier 384-well plate at a density of 10,000 cells per...
(Gal-4)27,28, have been related to axon growth and guidance, differentiation of microglia and oligodendrocytes, or nerve regeneration. LacNAc-dependent sorting of contactin suggested the participation of galectin interactions in myelin organization, according to our previous report of a directional Gal...