The deposition of vWF and blood coagulation may drive tumor metastasis [42]. Our results suggest that the vWF mutation associated with F. nucleatum may have an impact on platelet adhesion, potentially contributing to chronic bleeding in the tumor and dysbiosis of the intestinal microenvironment. ...
(A–I) Top 3 pathways enriched in PaCa TE EVPs compared to matched pancreas AT EVPs using Hallmark, KEGG, and GO gene sets, respectively. (A–C) Hallmark enrichment plot, heatmap, and protein list for (A) EMT, (B) coagulation, and (C) TGF-beta pathway. (D–F) KEGG enrichment ...
Skin fibroblasts express gene modules of diverse functions far exceeding their role as matrix-producing reparative cells, reflecting a wide range of potential functions in fibrosis, inflammation, immune responses, metabolism, angiogenesis, vascular and blood pressure modulation, coagulation, and neurogenesis...