Current thresholds to define chronic kidney disease (CKD) are essentially based on two measures, estimated GFR (eGFR) and albuminuria. The first two stages (stage 1 and 2) are mainly defined by the presence of abnormal albuminuria (>30 mg/g creatinine). Conversely, overt CKD (stages 3-5)...
229 kidney cells. Heritability analysis reveals that methylation variation explains a larger fraction of heritability than gene expression. We present a multi-stage prioritization strategy and prioritize target genes for 87% of kidney function loci. We highlight key roles of proximal tubules and ...
We found that the expression levels of ENPEP, GDPD3, NAGA, NEDD4L, QPRT, and SCAMP3 proteins in urine EVs were significantly higher (p-value < 0.05, calculated using the unpaired two-sample Wilcoxon test) in males than in females (Supplementary Fig.6a). There were positive correlatio...
We found that the expression levels of ENPEP, GDPD3, NAGA, NEDD4L, QPRT, and SCAMP3 proteins in urine EVs were significantly higher (p-value < 0.05, calculated using the unpaired two-sample Wilcoxon test) in males than in females (Supplementary Fig.6a). There were positive correlatio...
In the discovery stage, a database could be used as a control for a disease group. In the validation stage, the candidate proteins/peptides could be selected from the database for MS-based or immuno-based validation. Many groups have analyzed the normal human urinary proteome using various ...
Acute kidney injury (AKI) is an important clinical problem which is associated with higher mortality, increased health resource utilization and increased risk for chronic kidney disease (CKD) [1-3]. Previously, more than 30 definitions of acute renal failure have been used in the literature, ...
(Fig.3b). We then traced back the biopsy samples collected during the mid-stage (second hospitalization) of the disease (October, 2015). FFPE-biopsies taken from skin at the very beginning of the disease, clot, kidney and liver were positive for HHV-6 sncRNA-U14. These results point ...