Accompanying the direct or indirect interaction with other TME constituents, such as the induction of proliferation and immune tolerance, inhibiting apoptosis, etc., a variety of biological behaviors can change. People’s understanding of the tumor microenvironment is getting deeper and deeper, and the...
Protein Kinase Cα and Protein Kinase Cδ Play Opposite Roles in the Proliferation and Apoptosis of Glioma Cells Protein kinase C (PKC) has been implicated in the proliferation and apoptosis of glial tumors, but the role of specific PKC isoforms remains unresolved. Co... R Mandil,E Ashkenazi...
with some changes occurring at gene promoters, and others occurring at intergenic or intronic regions (Fig.1C). Many of the associated genes have been investigated in the context of osteosarcoma metastasis, but underlying mechanisms contributing to their aberrant expression remain unclear....
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Anna Rodina,Maria Vilenchik,Kamalika Moulick,Julia Aguirre,Joungnam Kim,Anne Chiang,Julie Litz,Cristina C Clement,Yanlong Kang,Yuhong She,Nian Wu,Sara Felts,Peter Wipf,Joan Massague,Xuejun Jiang,Jeffrey...
Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis Sci. Rep., 5 (2015), p. 16437 Google Scholar Shin et al., 2011 H.J. Shin, S.B. Rho, D.C. Jung, I.O. Han, E.S. Oh, J.Y. Kim Carbonic anhyd...
Describe Apoptosis and explain does it cause in the cell? (a) Describe the structure of the chromatin. (b) Describe its function. Explain how bacteria cells make energy for cellular processes. Describe the functions of the following organelles: (a) Flagella, (b) Ce...
Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes Matrix Biol., 94 (2020), pp. 110-133, 10.1016/j.matbio.2020.09.003 Google Scholar 103 V. Lefebvre Chapter Seven - Roles and regulation of SOX tr...
The identification of oncogenic signaling pathways that allow cell transformation, tumor growth and chemotherapy failure has greatly increased the knowledge of tumor cell biology, leading to a paradigm shift in cancer treatment. Initially performed with large populations and unc...
Disruption of GTP binding can prevent tubulin polymerization and may lead to microtubule disassembly20, leading to apoptosis21. Since GTP binds at the interface between α and β tubulins, we compared its binding energy to wild-type vs. mutant heterodimers. For this purpose, we replaced wild-...
apoptosis inhibitory protein) in which functional copy number variation is linked to increased cell death uponLegionella pneumophilainfection31; and secretoglobins (Scgb members), which may be involved in tumor formation and invasion in both human and mouse32,33. Large gene families in which little...