Heart regeneration is an unmet clinical need, hampered by limited renewal of adult cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging, but unravelling cellular dynamics of host–graft crosstalk remains elusive. Here
− cancer stem cell‑like subpopulation in the pre‑invasive niche Jiaxin Li1,2* , Fredrik Ek4, Roger Olsson4, Mattias Belting5,6,7 and Johan Bengzon1,2,3 Abstract Glioblastoma (GBM) is the most common and most aggressive primary brain tumor in ...
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and age
We profile immune responses in a unique model of differential lentiviral pathogenicity where pig-tailed macaques are infected with highly genetically similar variants of SIV that differ in virulence. We apply longitudinal single-cell transcriptomics to this cohort, along with single-cell resolution cell...
The secretome is defined as the complete set of Excreted/Secreted (ES) proteins of a cell [12]. These proteins play a critical role in biological processes important for gut colonization, persistence, interaction with mucosal cells, activating signaling pathways, contributing to probiotic effects, et...
Wood, C.G. Molecular markers of prognosis in renal cell carcinoma: Insight into tumor biology helps define risk and provides targets for therapy. J Surg Oncol 2006; 94(4):264-5.Wood CG. Molecular markers of prognosis in renal cell carci- noma: Insight into tumor biology helps define risk...
The src family tyrosine kinase p59fyn binds to a signaling motif contained in subunits of the TCR known as the immune-receptor tyrosine-based activation mo... LKT Gauen,LAS Shaw - 《Journal of Cell Biology》 被引量: 0发表: 1996年 Multiple features of the p59fyn src homology 4 domain ...
modulate host cell processes and to suppress or trigger host defences [4,5,6,7]. Although there is one recent report of the BISP effector from brown planthopper, an aphid relative, interacting with the Bph14 NLR in rice [8], there are currently no examples where cognate aphid effector and...
(Supplementary Fig.1b–e). RNA element specificity was shown by agonist-induced SARS-CoV-2 sgRNA reporter expression in all four cell types, whereas expression of the non-sgRNA reporters was generally unchanged, or decreased in the case of IFN-γ-treatment of non-sgRNA reporters in A549-h...
Describe the inheritance of sickle cell disease. Include the terms genotype, phenotype, homozygous, heterozygous, dominant, and recessive in your description. What is the difference between a phenotype and a genotype? What is the difference between phenotype and genotype? How does a heterozygous organ...