Some B-cell epitopes are conformational (as in VLPs), being formed by the juxtaposition in three-dimensional space of amino acid residues from different portions of the polypeptide, meaning that such epitopes require the full polypeptide for proper immunogenicity. In contrast, other peptide epitopes ...
Parameters for this type of scoring function are usually derived from both experimental data and ab initio quantum mechanical calculations. The major challenge for physics-based scoring functions is the treatment of the solvent in ligand binding. To overcome this limitation, implicit solvent approaches ...
meaning that after you analyze and annotate your protein sequence, you can immediately performprotein structure analysis, as well aspredict protein structure, performantibody modeling, or evaluateprotein-protein dockinginteractions. Use Protean 3D to have everything you need for comprehensive protein sequen...
and propose renaming it TumE (meaning ‘dark’ in Estonian), with the antitoxin components dubbed as TumA, with A for antitoxin. This example illustrates the difficulty of automating functional annotation for proteins from completely new superfamilies. Here, the combination of genomic context...
As has been suggested earlier, the slow refolding of DM-MBP is thought to be due to the presence of an entropic barrier25meaning that, in the absence of the hydrophobic core, a wide conformational search on a flat energy landscape needs to be performed. If this were the case, we should...
Yeast prions have several properties that, in principle, make them excellent candidates for building stable synthetic memory [225]. First, they exhibit bistability, meaning that a given cell can stably exist in either a [prion−] or [PRION+] phenotypic state. Second, cells can reversibly trans...
Proteins are polymers, and yet the language used in describing their thermodynamics and kinetics is most often that of small molecules. Using the terminology and mathematical descriptions of small molecules impedes understanding why proteins have evolved to be big in comparison. Many properties of the...
For example, structural word GSUS has a Lp max value equal to 140 and a nbsf*value equal to 3, meaning that this word is over-represented in three SCOP superfamilies and very strongly in one of them with a Lp score equal to 140, i.e. a p - value equal to 10-140. Average values...
Tα1, a neuron-specific microtubule protein, is expressed in the progenitor cells in retina and reaches its peak at one day after ONI, meaning that some stem cells start to produce new cells [125,126]. Krüppel-like factor 6a/7a (KLF6a/7a), a transcriptional factor binding to G/C-...
Unless defined otherwise herein, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs (See e.g., Singleton et al., DICTIONARY OF MICROBIOLOGY AND MOLECULAR BIOLOGY, 2D ED., John Wiley ...