Natural antibodies (nAbs) against aggregation-prone proteins have been found in healthy normal subjects. These proteins likely have a pathogenetic role in neurodegenerative diseases of ageing. They include the amyloid β (Aβ) protein which may play an i
Lower serum L-tryptophan availability in depression as a marker of a more generalized disorder in protein metabolism Neuropsychopharmacology 1996 15: 243–251 Article CAS Google Scholar Smith KA, Fairburn CG, Cowen PJ . Relapse of depression after rapid depletion of tryptophan Lancet 1997 349: ...
Elevated Kallikrein-binding protein in diabetes impairs wound healing through inducing macrophage M1 polarization. Cell Commun Signal. 2019;17(1):60. doi:10.1186/ s12964-019-0376-9 10. Chao J, Chao L. Experimental kallikrein gene therapy in hyperten sion, cardiovascular and renal diseases. ...
enters human cells by engaging angiotensin-converting enzyme 2 (ACE2)1. This interaction may lead to an imbalance of the renin-angiotensin-aldosterone system (RAAS), a potential mechanism contributing to this pathogen’s virulence2. A combination of ...
Institute of Medicine of the National Academy of Science, Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC National Academy Press2002; 50. US Department of Health and Human Services and US Department...
combined. Association analysis was performed using a linear mixed model implemented in BOLT-LMM v2.3.2 (https://data.broadinstitute.org/alkesgroup/BOLT-LMM/) with covariates for age, age-squared, and first ten genetic principal components. The replication analysis for fractures (ICD codes S22–...
Indeed, it has been experimentally shown that TAM disrupts an estrogen-driven interaction between ER and 4ICD while promoting mitochondrial accumulation of the 4ICD/BH3-only protein [36]. Accordingly, it seems plausible that a 4ICD/ER interaction impairs TAM binding and reduces treatment efficiency...
, 10.). The CREM protein family comprises >20 isoforms in humans, and there is broad evidence that the CREMα isoform is robustly overexpressed in SLE T cells. CREMα gene transcription itself is regulated through different promoters (denoted P1 and P2), and activity levels of P1 correlate ...
because viral vector vaccinations are known to be associated with certain typical adverse reactions. Preliminary results from this trial indicate that as expected, Meningococcal vaccine does not induce antibody responses against SARS-CoV-2 spike protein. It may be interesting to evaluate the antibody re...
Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat. Med. 7: 847-852.Jiang XC, Qin S, Qiao C, Kawano K, Lin M, Skold A, Xiao X, Tall AR: Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid...