In the GSTM1 null genotype workers, there is a dose-response of lung function tests (FEV1, FEV1/FVC, MMEF) for ECH exposure, but not in the GSTM1 non-null genotype workers. The ECH exposure was found to be significantly associated with a decreased FEV1 value (P = 0.09) and a ...
In the control group, serum α-Klotho concentrations did not correlate with any parameter of lung function tests (FVC (Rho −0.10; p = 0.22), FEV1 (Rho −0.11; p = 0.16), and DLCO (Rho 0.039, p = 0.63). Likewise, no association was observed with the levels of CRP...
aAdjusted by age, sex, smoking, biomass as fuels and drinking under additive model. Traits FEV1 FVC FEV1/FVC FEV1/FEV1-predicted The distribution of lung function traits on nsv823469 0-copy N M ± SE 110 2.69 ± 0.85 110 3.24 ± 0.94 110 0.83 ± ...
A Study of Pirfenidone Solution for Inhalation in Healthy Volunteers, Smokers or Former Smokers with Decreased Lung function, and Patients with Idiopathic Pulmonary Fibrosis (IPF) to determine pharmacokinetics, as well as the safety and tolerability in v
Measurements and main results: We enrolled 45 patients, with mean age (SD) of 67 (±8) years and mean FEV1 of 41 (± 10) % of predicted value. Thirty one percent (n=14) of patients had potentially pathogenic microorganisms in quantitative bacterial cultures of samples obtained by protected...
Results: Indexes of lung function including FEV1,FEV1/FVC,FEF25% and FEF50% were significantly improved after 9 days' treatment( P 0. 05),and better improvement in pulmonary function were found in the observation group than that in the control group( P 0. 05). Decreased concentrations of ...
Specifically, we found lower FEV1, (L/s) (=0.16, 95% CI 0.30 to 0.02, p=0.03) and FVC (L) (=0.17, 95% CI 0.34 to 0.01, p=0.06) per 10-fold increase of total dialkylphosphate levels.ConclusionsEarly-life organophosphate exposure as assessed by dialkylphosphate concentrations was ...
Similarly, the aOR of having VDD for men also increased with decreasing quartiles of FVC and FEV1 in a dose-response manner (p for trend < 0.01 for both). However, neither FVC nor FEV1 was associated with VDD in women. Conclusions: VDD was associated with decreased lung function in ...
Normal sub- jects were recruited from spouses of the patients and from the general population who answered negatively to a screening questionnaire for respiratory symptoms and had FEV1 greater than 75% predicted, PC20 methach- oline greater than 10 mg/ml, and normal findings on a simple chest...
FEV1%lung functionBackgroundExposures to indoor biological contaminants have been implicated in asthma's aetiology but their effect on lung function is not well quantified.McSharry, C.Vesper, S.Wymer, L.Howieson, S.Chaudhuri, R.Wright, G. R.Thomson, N. C....