In the total group, plasma sRAGE was positively associated with FEV1 and forced vital capacity and negatively with pack-years smoked. In patients receiving LTOT, levels of plasma sRAGE were lower compared with those without LTOT. Only in controls, a weak correlation was found between plasma sRAGE...
REDUCED MECHANICAL EFFICIENCY IN COPD, BUT NORMAL PEAK VO2 WITH SMALL MUSCLE MASS EXERCISE We studied 6 patients with COPD (FEV1 = 1.1 卤 0.2 L, 32% of predicted) and 6 age and activity level matched,controls while performing both maximal,bicycle... RS Richardson,BT Leek,TP Gavin,... ...
COPD patients with positive cultures had lower levels of MUC2 both in BAL (p=0.02) and in sputum (p=0.01). No differences in MUC5B and MUC5AC levels were observed among groups. Lower MUC2 levels were correlated with lower FEV1 (r=0.32, p=0.04) and higher sputum IL-6 (r=-0.40, p...
Moreover, the pulmonary function-based family analysis showed that the loss allele has a tendency to transmit to offspring/siblings with relatively high FEV1. Altogether, nsv823469 contributes to COPD predisposition and phenotypic pleiotropy. In addition, the family-based designs gave high credibility ...
Normal sub- jects were recruited from spouses of the patients and from the general population who answered negatively to a screening questionnaire for respiratory symptoms and had FEV1 greater than 75% predicted, PC20 methach- oline greater than 10 mg/ml, and normal findings on a simple chest...
COPDinducedsputummyeloperoxidaseoralglucocorticoidstreatmentBackgroundInhaled glucocorticoids may decrease exacerbations in some patients with COPD, and oral glucocorticoids may improve FEV1 and shorten hospital stay during exacerbations. The mechanism of these improvements is unknown. This study examines the ...
We also measured pulmonary function and the 6MWT distance.Forced expiratory volume in 1鈥卻 (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On ...
Finally, CD207+ cells were inversely related to FEV1 (p < 0.05).Our results show a reduced maturation of DCs in COPD that was related to airway vascularity and angiogenic factors (VEGF and TGF-β). Additionally, immature DCs were significantly related to disease severity. We propose that the...
The levels of IL-35 in plasma showed a positive correlation with FEV1% and FVC% in asthmatic patients whose plasma IL-35 values were over 150 pg/ml. A positive correlation was also found between plasma IL-35 and FVC% in COPD patients whose plasma IL-35 values were over 150 pg/ml....
In the elderly, male sex, low body mass index (BMI), insulin therapy, and high C-peptide immunoreactivity levels were factors related to COPD. In the non-elderly, age, female sex, high BMI were factors related to decreased FEV1% predicted. Female sex was factor related to decreased FEV1%...