We also measured pulmonary function and the 6MWT distance.Forced expiratory volume in 1鈥卻 (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On ...
Moreover, the pulmonary function-based family analysis showed that the loss allele has a tendency to transmit to offspring/siblings with relatively high FEV1. Altogether, nsv823469 contributes to COPD predisposition and phenotypic pleiotropy. In addition, the family-based designs gave high credibility ...
COPD patients with positive cultures had lower levels of MUC2 both in BAL (p=0.02) and in sputum (p=0.01). No differences in MUC5B and MUC5AC levels were observed among groups. Lower MUC2 levels were correlated with lower FEV1 (r=0.32, p=0.04) and higher sputum IL-6 (r=-0.40, p...
Normal sub- jects were recruited from spouses of the patients and from the general population who answered negatively to a screening questionnaire for respiratory symptoms and had FEV1 greater than 75% predicted, PC20 methach- oline greater than 10 mg/ml, and normal findings on a simple chest...
Drug: Salbutamol: Cohorts 1-3: If forced expiratory volume in one second (FEV1) in two or more subjects in any ascending dose cohort falls by greater than 10% at 15 minutes, all subsequent subjects will be pretreated with salbutamol. Otherwise, Cohort 4 will not receive pretreatment with ...
In the total group, plasma sRAGE was positively associated with FEV1 and forced vital capacity and negatively with pack-years smoked. In patients receiving LTOT, levels of plasma sRAGE were lower compared with those without LTOT. Only in controls, a weak correlation was found between plasma sRAGE...
Forced expiratory volume in 1鈥卻 (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On multivariate analysis, left ventricular stroke volume was the ...
Finally, CD207+ cells were inversely related to FEV1 (p < 0.05).Our results show a reduced maturation of DCs in COPD that was related to airway vascularity and angiogenic factors (VEGF and TGF-β). Additionally, immature DCs were significantly related to disease severity. We propose that the...
The diagnosis of COPD required both chronic airway obstruction (CAO) and the presence of respiratory symptoms, in line with the GOLD documents since 2017. CAO was defined as post-bronchodilator FEV1/FVC < 0.70, with sensitivity analyses based on the FEV1/FVC < lower limit of normal (LLN) ...
the presence of ILA may be associated with progression and lower survival rates among older individuals. In this context, we evaluated the serum levels of α-Klotho in 20 individuals of this cohort, after 1-year follow-up, and again we found a positive correlation with FVC and FEV1, although...