To test the hypothesis that the essential fatty acid, linoleic acid, measured in adipose tissue as an indicator of long term dietary intake, is inversely related to the risk of sudden cardiac death.A population case-control study.A regional health district.84 men (age 25-64 years) who died...
Similar problems arise, but on a vastly larger scale, when the brain is dead but the heart (and other organs) are kept going artificially. Under such circumstances, it can be argued, the organism as a whole may be deemed dead, although the majority of its cells are still alive. The “...
Death is necessary to exploit to the fullest the advantages of sexual reproduction. In Sex and the Origins of Death, William Clark ranges far and wide over fascinating terrain. Whether describing a 62-year-old man having a major heart attack (and how his myocardial cells rupture and die), ...
Programmed cell death (PCD) as a subset of regulated cell death includes classical apoptosis in the context of development and tissue homeostasis, and other forms that occur in the microenvironment of exogenous or endogenous perturbations, such as necroptosis, pyroptosis, autophagy, ferroptosis, etc [...
Mitophagy in ischemic heart disease: molecular mechanisms and clinical management Shujuan Xu Zihan Wang Jianhua Fu Review ArticleOpen Access30 Dec 2024 GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma ...
18. Matsuo H, Watanabe S, Watanabe T et al (2007) Prevention of no-reflow/slow-flow phenomenon during rotational atherectomy—a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil. Am Heart J 154(5):994.e1-994.e6. https://doi.org/10.1016/j....
13Altmetric Metrics Abstract Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses. Whereas it initially was depicted as the main form of cell death in...
Collagenase B (5 mL of 1 mg/mL) (Roche, Basel, Switzerland, 11088815001) in HBSS was added to the heart tissue, pipetted 10–15 times, and incubated in a 37 °C water bath for 5 min with gentle shaking. The supernatant containing the cells was transferred to fresh Dulbecco’s ...
death of an organism triggers a cascade of events that ultimately, in a relatively short time frame, lead to cell death and autolysis. Although DNA is known to be relatively stable over long post-mortem periods, RNA is much more labile in nature, and sensitive to degradation in a tissue-...
Autophagy and Autophagic Cell Death in the Heart To explain how autophagy can kill cells under some conditions, we will first describe the physiological function of autophagy and its molecular machinery. Autophagy is an essential catabolic process that is highly conserved in eukaryotes. The autophagy ...