Of note, co-culturing impaired mitochondria-containing microglia with untreated neurons propagates oxidative stress to previously healthy neurons, indicating that introducing compromised mitochondria can harm beyond the initially affected cells. This underscores the importance of preserving mitochondrial quality ...
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase complexes, with an emergent role in the DNA damage response and cell survival control. The regulation of CDC25A activity and ...
Introduction The Ki-67 protein is a prominent proliferation marker used in pathology [1,2]. Ki-67 was first identified as an antigen for a monoclonal antibody detected in the nuclei of proliferating cells [1,3]. For a long time, the function of this protein remained obscure, even after an...
I don’t want to discount the psychological implications of an Ottawa-T-ONto* series but if the Sens made their first serious run in 10 years (Ed Note: fuuuuck) the last thing on my mind would be “Ahh but we didnt fade the most fadeable team on the wayyy tho.” Maybe its the de...
Note that in addition to the original Mandarin audio, the Blu-ray comes with an English dub. I sampled some of it and found it predictably awful in terms of acting quality. As we shift to extras, we open with anaudio commentaryfrom film professor David Desser. He offers a running, scree...
2b). Out of these, the DUB USP7 is of special interest, as it has been implicated in neural progenitor cell maintenance before [6, 7]. Fig. 2 Identification of ubiquitination-related proteins associated with TRIM32 via mass spectrometry. a Enriched biological process GO term analysis (...
and cytokine genes known to be important regulators of blood cell survival and development were analyzed on the mRNA level by qPCR. Of note, among the pro-apoptotic genes of interest, in particular highly significant increases in p19ARFmRNA of up to 100-fold were detectable in total Mysm1-def...
It is interesting to note that TGF-β promotes cortical spine development through promoting USP9X-dependent stabilization of ankyrin-G [145] and that TGF-β signaling can rely on primary cilia [213]. This raises the intriguing possibility that the aforementioned pathogenic mechanisms may be interconn...
5D). It is interesting to note the differential response of the cell lines to cisplatin treatment, where ONS76 cells significantly increase their protein levels of BCL-XL and MCL-1, and thus their buffering capacity against pro-apoptotic proteins, UW228 cells increase their dependence on BCL-XL...