What are the core regulators that connect the communication of mitochondria trancstption and nuclear? Are there differences between mitochondrial transcription dysregulation and cancer cells and cancer stem cells? How to target the mitochondrial transcription in cancer without affecting the normal cells? In...
T cells encompass a broad range of effector, memory and regulatory subpopulations; each defined by distinct phenotypic characteristics and effector functions. While T cells play a fundamental role in mediating protection against infection and cancer, their responses need to be tightly regulated to preven...
regulators constitutes a positive feedback loop in the terminal phase of apoptosis, removing apoptotic inhibitors and promoting caspase activation. It is interesting to note that certain viral Bcl-2 proteins can also be cleaved by caspases, but in these cases no proapoptotic fragments are generated....
It is interesting to note that USP32 can influence the development of small-cell lung cancer’s cell cycle. USP32 knockdown increased apoptosis in addition to causing cell cycle arrest in the G0/G1 phase, with concomitant increases in Caspase3, cleaved PARP and P53-related apoptotic proteins....
International Journal of Molecular Sciences Article ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells Thiago Aparecido da Silva , Patrícia Kellen Martins Oliveira-Brito, Thiago Eleutério Gonçalves, Patrícia Edivânia Vendruscolo and Maria Cristina ...