593 (UPS), and the DUB-like enzyme PLpro whose activity plays a role in the pathogenesis of the topical SARS-CoV-2 pandemic. Ubiquitination in the regulation of inflammasomes and cell death Ubiquitination in TNF-mediated signaling Ubiquitination plays a critical role during TNF (tumor necrosis ...
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
properties as a ubiquitin-modifying enzyme, displaying deubiquitinating (DUB), E3 ubiquitin ligase, and ubiquitin-binding activities [161]. ZnF4, the domain of A20 with E3 ubiquitin ligase activity, has been shown to bind to K63-linked ubiquitin chains on complex I components [162]. This is ...
(I:C) and TNF-α treatments, respectively, were also significantly decreased by infection or PLpro expression [190]. This shows a clear role for the DUB/deISGylation activity of PLpro in the suppression of both IFN and NF-κB signaling pathways, and may contribute to the pathogenesis of ...
3. Traffic on the Highway—ER Stress Signaling and Biotrophic Pathogens 3.1. Defense Hormone Salicylic Acid Activates ER Stress Signaling The link between SA and ER stress signaling was originally established based on the observation that in Arabidopsis the application of SA leads to drastic changes...
Other relevant CD4+ T cell populations are Th17 cells, which express the transcription factor RORγt and produce IL-17A, and regulatory T cells (Tregs), which express FoxP3 and regulate the activation of T cells [20]. The differentiation of CD8+ T cells into cytotoxic T lymphocytes (CTLs...
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