Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan Toshiaki Iba Medical Intensive Care Unit - NHC, Strasbourg University (UNISTRA), Strasbourg University Hospital, INSERM (French National Institute of Health and Medical Research), UMR 1260, Regene...
properties as a ubiquitin-modifying enzyme, displaying deubiquitinating (DUB), E3 ubiquitin ligase, and ubiquitin-binding activities [161]. ZnF4, the domain of A20 with E3 ubiquitin ligase activity, has been shown to bind to K63-linked ubiquitin chains on complex I components [162]. This is ...
The other TNF signaling–associated DUB, CYLD, is a USP domain–containing DUB with specificity for K63-linked and linear ubiquitin chains [71,72]. CYLD is recruited to the TNFR complex in a LUBAC-dependent fashion through interaction bridged by the adapter protein SPATA2 (Spermatogenesis Associ...
Fig. 1: siRNA DUB screen in human muscle cells under differentiation condition. AA scheme of the screen assay.BBar charts show fusion index and nuclei count of the respective DUB siRNA transfections. Red line depicts a 37.5% fusion index cut-off, which is half the fusion index of untreated ...
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Other relevant CD4+ T cell populations are Th17 cells, which express the transcription factor RORγt and produce IL-17A, and regulatory T cells (Tregs), which express FoxP3 and regulate the activation of T cells [20]. The differentiation of CD8+ T cells into cytotoxic T lymphocytes (CTLs...
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Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In most cases, patients with NSCLC are already at an advanced stage when they are diagnosed. In recent years, lung cancer has made great progress in
Non-small cell lung cancer (NSCLC) is one of the most threatening malignancies to human health and life. In most cases, patients with NSCLC are already at an advanced stage when they are diagnosed. In recent years, lung cancer has made great progress in
593 (UPS), and the DUB-like enzyme PLpro whose activity plays a role in the pathogenesis of the topical SARS-CoV-2 pandemic. Ubiquitination in the regulation of inflammasomes and cell death Ubiquitination in TNF-mediated signaling Ubiquitination plays a critical role during TNF (tumor necrosis ...