593 (UPS), and the DUB-like enzyme PLpro whose activity plays a role in the pathogenesis of the topical SARS-CoV-2 pandemic. Ubiquitination in the regulation of inflammasomes and cell death Ubiquitination in TNF-mediated signaling Ubiquitination plays a critical role during TNF (tumor necrosis ...
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
TNF controls inflammatory signalling and cell fate through binding to two distinct receptors: TNFR1 and TNFR2, which are differentially expressed in different cell types. TNFR1 contains a death domain (DD) in its cytoplasmic tail, whilst TNFR2 lacks a DD [1,2]. The single-cell response to ...
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range of enzymes including E1s, E2s, and E3s, and an array of DUBs. The
Keywords: plant immune responses; IRE1; programmed cell death; ER stress signaling; Arabidopsis 1. Introduction In order to defend themselves against diseases, plants rely on early recognition of pathogens followed by fast responses to eliminate the attacker. The plant immune system contains several ...
Keywords: CD4+ and CD8+ T cells; Jurkat T cells; lectins; ArtinM; immunomodulation 1. Introduction Most mammalian cellular and membrane-bound proteins are glycosylated, implying that carbohydrates have an essential role in determining the functions of proteins and cells [1]. Interactions involving ...
Death (ROD) Pathogen in Hawaiian Forestsectral Mapping Signature for the Rapid OhiaArticAlerticle 4 Institute of Pacific Islands Forestry, US Forest Service, Hilo, HI 96720, USA; fhughes@fs.fed.us * Correspondence: gpa@ciw.edu; Tel.: +1-650-325-1521 h (ROD) PatAhoSAgpeSencpitenrcaHtl...