593 (UPS), and the DUB-like enzyme PLpro whose activity plays a role in the pathogenesis of the topical SARS-CoV-2 pandemic. Ubiquitination in the regulation of inflammasomes and cell death Ubiquitination in TNF-mediated signaling Ubiquitination plays a critical role during TNF (tumor necrosis ...
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
Death (ROD) Pathogen in Hawaiian Forestsectral Mapping Signature for the Rapid OhiaArticAlerticle 4 Institute of Pacific Islands Forestry, US Forest Service, Hilo, HI 96720, USA; fhughes@fs.fed.us * Correspondence: gpa@ciw.edu; Tel.: +1-650-325-1521 h (ROD) PatAhoSAgpeSencpitenrcaHtl...
Keywords: plant immune responses; IRE1; programmed cell death; ER stress signaling; Arabidopsis 1. Introduction In order to defend themselves against diseases, plants rely on early recognition of pathogens followed by fast responses to eliminate the attacker. The plant immune system contains several ...
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Fig. 1: siRNA DUB screen in human muscle cells under differentiation condition. AA scheme of the screen assay.BBar charts show fusion index and nuclei count of the respective DUB siRNA transfections. Red line depicts a 37.5% fusion index cut-off, which is half the fusion index of untreated...
Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and ne
Combining anti-PD-1/PD-L1 drugs with chemotherapy or other ICIs (such as those targeting CTLA-4) can improve the prognosis of patients with NSCLC. In the randomized, phase III KEYNOTE 407 trial, compared with chemotherapy alone, the addition of pembrolizumab to chemotherapy with carboplatin plus...
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast number of cellular processes. Ubiquitination is tightly regulated at different levels by a range of enzymes including E1s, E2s, and E3s, and an array of DUBs. The