Historic trends in mortality show seasonality in the number of deaths throughout the year, with the number of deaths higher in the winter and lower in the summer. The eFigure in the Supplement shows that death counts by week from 2015 to 2019 followed a normal seasonal pattern, with higher...
Table 1. Findings From Observational Studies on the Association of Time During Opioid Agonist Treatment (OAT) and Out of OAT With All-Cause Mortality According to Demographic, Clinical, and Study-Level Variables View LargeDownload Table 2. Findings From Observational Studies on the Pooled All-Cause...
As expected, all SLE samples with high anti-APEX1 titer by ELISA assays also showed strong binding with APEX1 protein at 35 kD, while weak or no binding was detected in the serum samples from NCs, which were also negative by ELISA (Figure 3). Download: Download high-res image (237...
The results indicate that AChE is produced by human GCs, whereas BChE in FF may mainly be derived from the circulation. AChE isoforms in cultured human GCs Reverse transcription-PCR (RT-PCR) strategies followed by sequencing allowed us to identify three AChE splice variants in human GCs: the ...
Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically actionable. Here we identify inhibition of mannose-6-phosphate isomerase (MPI), the first enzyme in the mannose metaboli...
β-actin is the loading control. (b) Densitometric analysis of two independent blots as in (a), showing ratio of caspase-3 toβ-actin. (c) qPCR was used to compare the amount of caspase-3 mRNA in PC3 clone KD1 and KD2 with normal PC3 cells as control to confirm the knockdown of ...
Next, we investigated whether PEBP1 and 15LOs are co-localized in multiple cell types using immunocytochemistry and confocal microscopy, followed by object-based co-localization analysis. HAECs express predominantly 15LO1 induced by IL-13, while HK2 kidney and HT22 neuronal cells express predominantly...
Growth factor-induced activation of protein kinase-B (PKB), also known as AKT, induces pro-survival signaling and inhibits activation of pro-apoptotic signaling molecules including the Forkhead box O-3a (FOXO3a) transcription factor and caspase in transf
(TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. ...
40. Reich DJ, Munoz SJ, Rothstein KD, Nathan HM, Edwards JM, Hasz RD, Manzarbeitia CY. Controlled non-heart-beating donor liver transplantation: a successful single center experience, with topic update. Transplantation. 2000;70:1159-1166. [PubMed] [Cited in This Article: 1] 41. Kacz...