a–dCell viability and LDH cytotoxicity induced by cinnamaldehyde (CA) in GC cells, including SNU-638, SNU-216, AGS, NCI-N87, MKN-45, and MKN-74, measured using WST-1 and LDH assays in a dose-dependent manner (0, 25, 50, and 100 μg/mL; 24 h) and a time-dependent manne...
which also leads to activation of replication stress and DNA damage response (DDR) in tumor cells. For example, this has been shown for splicing factors, such as NHP2L1/
We did not screen for these pathways in other brain regions including substantia nigra or cortex, meaning that melatonin can alleviate glucocorticoid-induced impaired mitophagy by increasing PINK1-parkin pathways in these regions. However, we could not detect this phenomenon in hippocampal neurons or ...