A gene on chromosome 2p24 that encodes a protein which contains a conserved Asp-Glu-Ala-Asp (DEAD motif) and acts as an ATP-dependent RNA helicase, which unwinds both RNA-RNA and RNA-DNA duplexes. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. Want to thank ...
An Arabidopsis ATP-dependent, DEAD-box RNA helicase loses activity upon IsoAsp formation but is restored by PROTEIN ISOASPARTYL METHYLTRANSFERASEdoi:10.1105/tpc.113.113456Orthodox seeds are capable of withstanding severe dehydration. However, in the dehydrated state, Asn and Asp residues in proteins can...
Keywords:DEADbox(multi)unctionalRNAhelicases(cancer)oncogene,tumorsuppressor Memberso,theDEADbox,amilyo,RNAhelicasesareknowntobeinvolvedinmostcellularprocessesthatrequiremanipulationo,RNAstructureand,inmanycases,exhibitother,unctionsinadditiontotheirestablishedATP-dependentRNAhelicaseactivities.Theythusplaycriticalrole...
DDX3 is a highly conserved member of ATP-dependent DEAD-box RNA helicases with multiple functions in RNA metabolism and cellular signaling. Here, we describe a novel function for DDX3 in regulating the mitochondrial stress response in the parasitic protozoanLeishmania.We show that genetic inactivatio...
Then, ATP hydrolysis triggers the release of the displaced RNA strand, restoring the original open conformation with the two RecA-like domains separated [6]. In contrast to the conserved helicase core, the N- and C-terminal extensions are variable and divergent in length and composition. These...
Keywords:RNAhelicase;DEAD boxRNAhelicase;neoplasm 1 引言 RNA解旋酶有 9个保守基序,其中含有能够结 合 RNA和 NTP的结构域.RNA解旋酶与 RNA结 合后可以激活 NTP酶的活性,水解 NTP产生能量促 使双链 RNA解链.DEAD boxRNA解旋酶(DEAD boxRNAHelicase,DDX)是 RNA解旋酶超家族成员 之一,因为其第二个基序含有...
transcriptional level. RNA helicases are involved in the formation of cytoplasmic ribonucleoprotein (RNP) granules and RNA silencing. A highly conserved central domain is characteristic of DEAD-box RNA helicases and determines their basic biological activity in ATP-dependent unwinding of short RNA ...
RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism. They are associated with many processes ranging from RNA synthesis to RNA degradation. DEAD-box proteins use the energy from ATP hydrolysis to rearrange inter- or intra-molecular...
Although KH domains have been found in a variety of proteins, no KH domain has been described in helicases. Here, we found that DDX43 protein could function as both an RNA and DNA helicase in an ATP-dependent manner. Intriguingly, DDX43 unwound duplex RNA regardless of single-strand tail ...
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J. 2008, 27, 2135–2146. [Google Scholar] [CrossRef] [Green Version] Oshiumi, H.; Sakai, K.; Matsumoto, M.; Seya, T. DEAD/H BOX 3 (DDX3) helicase binds the...