The DEAD-box ATP-dependent RNA helicase DDX5, which plays an important role in many aspects of cellular RNA biology, was also found to either promote or inhibit viral replication upon infection with several RNA viruses. Here, our aim is to examine the impact of ...
登革病毒非结构蛋白NS3是一种多功能蛋白,N端具有Ser蛋白酶活性,C端具有RNA解旋酶及NTP磷酸酶、5'RNA三磷酸酶等活性,参与病毒前体的加工和病毒RNA的复制及基因组RNA的5'端加帽。 2. The P68 nuclear protein is an ATP-dependent RNA helicase a nd RNA-dependent ATPase, and has been proved to have functi...
In the absence of ATP and RNA, these two RecA-like domains of the helicase core move freely and are flexible with respect to each other (open conformation). The collaborative binding of ATP and RNA, stimulates these two domains to form a closed position (closed conformation), to induce ATP...
RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism. They are associated with many processes ranging from RNA synthesis to RNA degradation. DEAD-box proteins use the energy from ATP hydrolys
DEAD box proteins use ATP to unwind short duplex RNA in an unusual fashion and remodel RNA–protein complexes, but they can also function as ATP-dependent RNA clamps to provide nucleation centres that establish larger RNA–protein complexes. Structural, mechanistic and molecular biological studies ...
Rm62 is an mRNA-binding protein with ATP-dependent helicase activity that has been implicated in alternative splicing =-=[34,35]-=-, making it a potent potential downstream target of SXL. Candidates CG11737 and blow are downstream of dsx in the soma Expression of the sex-specific transcripts...
Memberso,theDEADbox,amilyo,RNAhelicasesareknowntobeinvolvedinmostcellularprocessesthatrequiremanipulationo,RNAstructureand,inmanycases,exhibitother,unctionsinadditiontotheirestablishedATP-dependentRNAhelicaseactivities.Theythusplaycriticalrolesincellularmetabolismandinmanycaseshavebeenimplicatedincellularproli,erationand...
RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highly structured 5′ UTRs that depend strongly on eIF4A-mediated unwinding5. However, rocaglate treatment may not phenocopy the loss of eIF4A activity, as...
A gene on chromosome 2p24 that encodes a protein which contains a conserved Asp-Glu-Ala-Asp (DEAD motif) and acts as an ATP-dependent RNA helicase, which unwinds both RNA-RNA and RNA-DNA duplexes. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. Want to thank ...
Abstract: The normal occurrence and maturation of sperm require the correct expression of many relevant genes. Therefore, the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving...