DEAD-box RNA helicases are involved in various aspects of RNA metabolism, including RNA transcription, premRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation and RNA decay. DEAD-box RNA解旋酶参与RNA转录、前体mRNA剪切、核糖体发生、核质运输、蛋白质翻译、RNA降解等重要的生命活动。
DEAD-box helicases interact with virus elements and host (or viral) proteins, to mediate translational initiation of viral RNAs. For example, DDX3X binds to the 7-methylguanosine 5′-triphosphate (m7GTP) cap of the HIV-1 RNA, interacts witheukaryotic translationinitiation factor 4G (eIF4G) and...
The review summarizes a current knowledge about a role of RNA helicases in the development and maintenance of gamenogenesis in eukaryotes. We focused on three RNA helicase family members—Vasa/DDX4, Belle/DDX3, and Spindle-E/TDRD9—that contain characteristic amino acid sequence motifs (DEAD b...
DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication Traditional functions of DExD/H-box helicases are concerned with RNA metabolism; they have been shown to play a part in nearly every cellular process that ... A Fullam - 《...
Background p68 (Ddx5) and p72 (Ddx17) are highly related members of the DEAD box family and are established RNA helicases. They have been implicated in growth regulation and have been shown to be involved in both pre-mRNA and pre-rRNA processing. More recently, however, these proteins hav...
The DEAD-box protein family of RNA helicases. Stationarity Is Dead: Whither Water Management? Spreading dead zones and consequences for marine ecosystems. Apoptotic pathways: ten minutes to dead. Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF ...
DNA helicases belong to a superfamily of proteins that is distantly related to DEAD/H box RNA helicases and includes the Werner syndrome protein (WRN) [2] and the Xeroderma pigmentosum XPB and XPD proteins [3], which have well established roles in transcription. Although the functions of DEAD...
we investigated the roles of DEAD-box helicases in the formation and alteration of membraneless nuclear dicing bodies (D-bodies) in Arabidopsis thaliana We uncovered that RNA helicase 6 (RH6), RH8, and RH12 are previously unidentified D-body components. These helicases interact with and promote...
DEAD-box helicases perform multiple functions, including RNA splicing, mRNA export, transcrip... K Nozaki,H Kagamu,S Shoji,... - 《Cancer Research》 被引量: 12发表: 2013年 Intracellular receptors for viral and bacterial infections (WS-056) Type I interferons (IFNs) play a pivotal role ...
In Physcomitrium patens, PpRH1/PpRH2 are GUCT-domain-containing DEAD-BOX RNA helicases localize to the nucleus. They are implicated in cell and tissue development in all stages of the moss life cycle. Abstract The DEAD-box-containing RNA helicase family encompasses a large and functionally...