This work makes explicit the considerable implicit knowledge that contributes to success in de novo protein design, and shows that citizen scientists can discover creative new solutions to outstanding scientific challenges such as the protein design problem....
由公民科学家Foldit玩家设计的蛋白质绝不逊色于专业蛋白质设计者:它们准确地折叠到预期的构象,显示出优异的折叠稳定性并跨越多种多样的结构。鉴于几年前de novo蛋白质设计几乎完全没有解决问题,这一结果更令人印象深刻,成功的Foldit玩家模型所涵盖的蛋白质折叠的多样性大大超过以往任何蛋白质设计报告中的蛋白质折叠,我...