We conclude that DCX in the piriform cortex marks a unique population of postmitotic neurons with a subpopulation that retains immature characteristics associated with synaptic plasticity. DCX is thus, per se, no marker of neurogenesis but might be associated more broadly with plasticity....
Our study showed a basal difference in immature neurons complexity between dorsal and ventral hippocampus. Cells from the DG of the dorsal hippocampus of animals fed with LFD showed a much greater dendritic complexity than those in the ventral hippocampus. However, despite the strict inclusion criteri...
immature neurons, lithium, Nestin-GFP transgenic mice, neurogenesis, quiescent neural progenitor cells Issue Section: Letter to Editor IntroductionThe term adult neurogenesis constitutes a series of developmental steps including the birth, survival, differentiation, maturation, and even death of newborn ...
Background:Doublecortin (DCX) is a microtubule-associated protein expressed almost exclusively in immature neurons. Neuronal precursors begin to express DCX shortly after exiting the cell cycle, and continue to express DCX for 2-3 weeks as the cells mature into neurons. Downregulation of DCX begins...
While one class of cells in the piriform cortex indeed showed features similar to newly generated immature granule neurons, the majority of DCX cells in the piriform cortex was mature and revealed large Na+ currents and multiple action potentials. Furthermore, when proliferative activity was assessed...
Cai Y et al (2009) Doublecortin expression in adult cat and primate cerebral cortex relates to immature neurons that develop into GABAergic subgroups. Exp Neurol 216:342–356 Article CAS PubMed Google Scholar Garden DL et al (2009) Anterior thalamic lesions stop synaptic plasticity in retrosplen...
(Fig.1C). For this reason we used it to evaluate the complexity of dendritic arborizations of DCX+cells23. We initially evaluated the effects of LFD and HFD on DCX+immature neurons in the dorsal DG (from Bregma − 0.94 to − 2.46 mm). In this region, DCX+cells of HFD animals ...