Doublecortin (DCX) is a protein required for normal neuronal migration in the developing cerebral cortex, where it is widely expressed in both radially and tangentially migrating neuroblasts. Moreover, it has been observed in the adult rostral migratory stream, which contains the neuronal precursors ...
Lithium treatment did not affect the percentage of Nestin-GFP/DCX double-positive cells (Figure 1E), indicating a lack of effect on type-IIb (neuroblasts). Lithium treatment also had no effect on the number of DCX-positive cells per section, indicating that immature neuron number was ...
Similarly, we did not observe changes in the expression levels of βIII tubulin, another established marker for newly born neuroblasts28(Fig.6B). Since long and short term HFD are associated with neuroinflammation29,30,31which may result in negative effects in adult born neurons/neuroblasts32, ...