This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of ...
DCLRE1C In subject area: Biochemistry, Genetics and Molecular Biology The Artemis gene (DCLRE1C) is a 78-kDa protein having 692 amino acids that span 56,665 base pairs and consists of 20 exons. From: Genes & Diseases, 2020 About this pageSet alert Discover other topics ...
Gene ID (NCBI) 64421 RRID AB_2090250 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q96SD1 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is ...
PCR-RFLP analysis was performed with primers containing mutation sites and appropriate restriction enzymes. Results: As a result of the analysis, 12 patients were homozygous mutant for DCLRE1C gene exon 3, 2 parents were heterozygous for exon 3, and 2 patients were heterozyg...
产品型号:abx004292 产品展商:其它品牌 产品文档:无相关文档 简单介绍 DCLRE1CAntibody DCLRE1C Antibody的详细介绍 DCLRE1CAntibodyis a Rabbit Polyclonal antibody against DCLRE1C. This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-st...
DCLRE1Cgene mutation leads to Artemis deficiency, a severe form of combined immunodeficiency (SCID). Impaired DNA repair and block in early adaptive immunity maturation results in T-B-NK+immunodeficiency associated with radiosensitivity. Recurrent infections early in life are the main characteristic of...
Here, we introduce an SCID mouse model with a targeted disruption of the dclre1c gene, encoding Artemis, which is essential for V(D)J recombination and DNA repair during T cell receptor (TCR) and B cell receptor (BCR) assembly. Artemis deficiency precipitates a profound immunodeficiency ...
Gene editingPorcineThe ability to efficiently introduce site-specific genetic modifications to the mammalian genome has been dramatically improved with the use of the CRISPR/Cas9 system. CRISPR/Cas9 is a powerful tool used to generate genetic modifications by causing double-strand breaks (DSBs) in ...
Background: The endonuclease ARTEMIS, which is encoded by the DCLRE1C gene, is a component of the nonhomologous end-joining pathway and participates in hairpin opening during the V(D)J recombination process and repair of a subset of DNA double-strand breaks. Patients with ARTEMIS deficiency ...
GeneID 64421 OMIM 65988 NCBI Accession NP_001029027.1 NM_001033855.2 [Q96SD1-1] NP_001029029.1 NM_001033857.2 [Q96SD1-2] NP_001029030.1 NM_001033858.2 [Q96SD1-2] NP_001276005.1 NM_001289076.1 [Q96SD1-3] NP_001276006.1 NM_001289077.1 [Q96SD1-2] NP_001276007.1 NM_001289078.1 [Q96SD1-3] NP...