Also, no available databases can be used to retrieve cancer-associated miRNA–target interactions. As the pathogenesis of human cancers is affected by several miRNAs rather than a single miRNA, it is needed to uncover miRNA synergism in a systems level. Here for each cancer type, we constructed...
and YAP1 or CAV1 overexpression in CAFs can highly induce directional migration and invasiveness of carcinoma cells [12,18,19]. CAFs also build up ECM structure through αvβ3 integrin and α5β1 integrin to support cancer cell [20]. On the...
Mutations of the human p53 gene are of importance in the development of cancer. Perhaps 50% of all human cancers contain a mutation in the p53 oncogene and many laboratories are investigating mutations at this locus. In an effort to centralize and standardize the information regarding human p53 ...
Gilbert and his FSU colleagues were part of a team that compared differentcancercell types to a database of normal humancellsusing a new method he developed that can identify the cell type from which cancers derive. By comparing variouscancer cellsto the collection of normal cells, they were a...
These cancer-related genes include members of “oncogenes” [2] and “tumor suppressor genes” [3], whose protein products are often involved in fundamental cellular functions, such as cell growth signal transduction [4], DNA repair [5], cell adhesion [6] and so on. Thanks to the human ...
Gene Expression Omnibus (GEO) is a public repository forfunctional genomicshousinggene expression profilingdata viamicroarrayand sequencing-based techniques. For this specific study, the datasets that were selected were searched using the keywords “colorectal cancer,”“Microarray,”“Homo sapiens,...
microCosm(218 microRNAs),PhenomiR(293 microRNAs),and mir2Disease(90 microRNAs) and target gene information such as the pathways like cell cycle regulation,angiogenesis,apoptosis etc.Though miRNA's are still to be explored,they hold a promise as therapeutic targets and diagnostic markers of cancer.CNK...
12, 13 Cell cycle inhibition of many human cancer lines has been observed in vitro; however, a mechanism of action is unclear.12, 13, 14, 15, 16 Apoptosis, as well as antitumor action, has been demonstrated, and rhubarb extract has been suggested as an adjunct to chemotherapy.12, 13, ...
The goal in company document collection is straightforward: to collect the annual reports of all listed companies in major economies.We strive to collect documents for all listed companies on all exchanges, that includes the main boards for established companies and junior markets for emerging companie...
1 Cell Death and Disease (2014) 5, e1272; doi:10.1038/cddis.2014.236; published online 29 May 2014 Subject Category: Cancer Dear Editor, In current cancer treatment, fighting against cancer with cytotoxic drug is often challenged by the emergence of chemotherapy resistance, because the patients ...