Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cycle checkpoints operate as DNA surveillance mechanisms...
Here, we analyzed the whole genomic, epigenomic, transcriptomic, and proteomic data of 155 esophageal squamous cellcarcinomas(ESCCs). Multi-omics analysis led to the classification of ESCCs into four subtypes: cell cycle pathway activation, NRF2 oncogenic activation, immune suppression (IS), and im...
Cell Cycle 5, 1744–1750 (2006). CAS PubMed Google Scholar Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105–111 (2001). CAS PubMed Google Scholar Coller, H. A., Sang, L. & Roberts, J. M. A ...
Cell division in mammalian cells is driven by protein kinases that regulate progression through the various phases of the cell cycle. Cyclin-dependent kinases (Cdks) regulate cell cycle commitment, DNA synthesis and the onset of mitosis. Kinases of the Aurora, Polo and Nek families participate in...
Tertiary lymphoid structures and B cells: Anintratumoral immunity cycle Published on September 11. ...
G2 is the gap after S phase when the cell prepares for entry into mitosis 4. G0 represents a state when cells have reversibly withdrawn from the cell division cycle in response to high cell density or mitogen deprivation 5. Alternatively, cells may irreversibly withdraw from the cell cycle ...
Fig. 2. sEVs secreted from 95D cells regulate the proliferation and the metastasis of recipient cells. A, MTS assay on cell viability of 95C cells treated with 10 μg/mL 95D-sEVs, and blank PBS, respectively. B, Flow cytometry on cell cycle profiling of the 95C cells treated with ...
Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, we compared growth and cell cycle events of
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much a
Kinases involved in cell cycle checkpoint function such as CHK1 and WEE1 also constitute potential therapeutic targets. Their inhibition compromises checkpoint function, causes excessive DNA damage and eventually leads to apoptosis, particularly in cells with compromised p53 function. CDK4/6-selective inh...