Dat-cre 品系类型 定点突变 基因型 染色体 13号染色体 品系背景 B6 毛色 黑色和agouti 品系描述 从基因座中去除一个frt侧翼的neo,使cre重组酶cDNA位于3' UTR中,允许双反子mRNA表达。将目标载体电穿孔入R1和C57BL/6 ES细胞。Cre重组酶活性早在胚胎第15天就被观察到,并与内源性基因表达在成年多巴胺能细胞群(黑...
The Dopamine Transporter DAT-Cre KI rat model was originally created at SAGE Labs, Inc. in St. Louis, MO and distributed out of the Boyertown, PA facility. The line continues to be maintained through the original SAGE Labs animal inventory acquired by Envigo, then Envigo was acquired by I...
HsdSage:SD-Slc6a3em1(Dat-cre)Sage Strain HsdSage:SD-Slc6a3em1(Dat-cre)Sage Location U.S. (Cryopreserved) Order Today +1 800 793 7287 Cryopreserved Typically heterozygous rats are cryo-recovered in 10-12 weeks to an age of 7 weeks old. Subsequently homozygous rats to an age of ...
2015. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines. Neuroscience 307: 319-337. DOI: https://doi.org/10.1016/j.neuroscience.2015.08.060, PMID: 26335381Vuong HE, Sevilla Müller LP, Hardi CN, McMahon DG, Brecha NC (2015) ...
dat cre ai140 小鼠 更新时间:2024年12月19日 综合排序 人气排序 价格 - 确定 所有地区 已核验企业 查看详情 ￥1260.00/件 上海 Mouse (Sema3g)ELISA Kit(ZY-E6738M)小鼠 ELISA试剂盒 泽叶生物品牌 上海泽叶生物科技有限公司 4年 查看详情 ￥1260.00/件 上海 Mouse (Sparcl1)ELISA Kit(ZY-E6650M)...
基本原理 在多巴胺转运蛋白 (DAT) 或酪氨酸羟化酶 (TH) 启动子的调控下表达 Cre 重组酶的转基因小鼠系通常用于研究多巴胺 (DA) 系统。虽然使用 TH 启动子似乎对天然基因表达的变化不太敏感,但 DAT 基因座中的转基因插入会导致 DAT 表达和功能降低。在以基因为目标的行为实
Subtle impact of the reduction in dopamine transporter (DAT) gene expression in DAT-Cre miceMingote, SusanaChohan, M OChuhma, NGellman, CeliaInbar, BRayport, SMoore, H M
were not changed compared to WT. These ef f ects were paralleled by dif f erences in striatal DAT expression that disproportionately af f ected female KI mice. Our fi ndings reveal clear limitations of the DAT‑Cre line that must be considered when using this model.Transgenic Cre recombina...
Heterozygous mice that express Cre-recombinase under the dopamine transporter promoter (DAT-Cre knock in mice, or KI) are widely used for targeting midbrain dopamine neurons, under the assumption that their constitutive physiology is not affected. We report here that these mice display striking sex...
DAT-IRES-Cre小鼠 评论:0条 收藏:0 性别:雄 / 雌 周龄:3～8周 繁育方式:纯合 X 纯合 品牌:鼠来宝生物 声明:仅用于科学研究,不得用于临床诊断或治疗 产品详情 产品评论(0) 友情链接: 微信公众号 Charles River Mouse Genome Informatics (MGI)