Definition of Terms Drug abuse Medication overuse. GABA (gamma-aminobutyric acid) The main inhibitoryneurotransmitterof the CNS with high concentrations in the cortex and in the limbic system. t½(elimination half-life) The time it takes for the concentration of a drug in the plasma to decrease...
Using multielectrode recording and optogenetic manipulations, we show that VIP neurons provide coordinated daily waves of GABAergic input to target cells across the paraventricular hypothalamus and ventral thalamus, supressing their activity during the mid to late day. Using chemogenetic manipulation, we...
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dose responsepopulation modelingvigabatrinepilepsypharmacologyVigabatrin is an irreversible inhibitor of 纬-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the ...
Acute caffeine intake has been found to increase working memory (WM)-related brain activity in healthy adults without improving behavioral performances. The impact of daily caffeine intake—a ritual shared by 80% of the population worldwide—and of
Increases of + counts were correlated with increases of colony-forming unit-granulocyte macrophage (peak, day 7). 展开 关键词: COCAINE STIMULANT ABUSE DOPAMINE AGONISTS AND ANTAGONISTS GABAERGIC TERMINALS DOI: 10.1016/0009-9236(95)90263-5 被引量: 45 年份: 1995 ...
Gamma-Aminobutyric Acid (GABA): A neurotransmitter that helps calm the nervous system and induce a state of relaxation, which can be beneficial for sleep and stress management. Melatonin: The primary hormone responsible for regulating the body’s circadian rhythm and sleep-wake cycle. Melatonin supp...
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suggesting exposure-specific effects. The substance that contributed the most to the classification, 5-aminovaleric acid, is known to act as a weak GABA receptor agonist [47,48]. GABA release is regulated by nicotinic acetylcholine receptors, and elevated liver concentrations of 5-aminovaleric acid ...
similar to a mess of tangled, ill working electrical wires. This is because the consumption of alcoholic beverages blocks the brain’s communicative conduits (where messages travel from the brain to other parts of the body and vice versa) and blocks neurotransmitters (i.e., glutamate and GABA...