胰岛素是一个重要的调节血糖的激素,主要由胰岛β细胞产生。胰高血糖素是一种由肝细胞产生的荷尔蒙,它在血糖升高时通过一系列的信号通路,促进胰岛β细胞释放胰岛素来降低血糖水平。在这个过程中,DAG-PKC信号通路在胰岛素的分泌中扮演着关键的角色。 DAG-PKC(signal transduction pathway)是指Diacylglycerol-Protein Kinase ...
group (P<0.05).Conclusion① High fat diet can increase insulin resistance,blood lipid level,and DAG-PKC pathway expression in mice.② DAG-PKC pathway expression has a positive correlation with IR.③ Probiotics can improve insulin resistance in obese mice,which may be related to DAG-PKC pathway...
暡关键词暢 暋 糖尿病心肌病; 暋 信号通路; 暋PKC 毬 2 ; 暋JNK1 ; 暋IRS1 暡中图分类号暢 暋R329暋暋 暡文献标识码暢 暋A暋暋 暋暋DOI : 10灡3870 / zgzzhx灡2014灡01灡009 InterventionofDAG灢PKCpathwayaffects JNK1andIRS1expressionindiabeticratmyocardium WangShengji 1* , WuWei 1* , FanXi...
Effects of DAG-PKC signaling pathway on cAMP-PKA signaling pathway in anti-inflammatory effects of CCK-8 Aim To investigate the effects of DAG-PKC signaling pathway on cAMP-PKA signaling pathway in anti-inflammatory effects of CCK-8.Methods PIMs were isolated ... WJ Gao,SJ Xu,B Cong,......
摘要:sn-1,2-diacylglycerol (sn-1,2-DAG)-mediated activation of protein kinase C ε (PKC ε ) is a key pathway that is responsible for obesity-related lipid metabolism disorders, which induces hepatic insulin resistanc...
CCK-8抗炎作用中DAG-PKC信号通路对cAMP-PKA信号通路的影响Effects of DAG-PKC signaling pathway on cAMP-PKA signaling pathway in anti-inflammatory effects of CCK-8 目的探讨CCK-8抗炎作用中DAG-PKC信号通路对cAMP-PKA信号通路的影响。方法分离纯化大鼠PIMs,分别用LPS、CCK、LPS+CCK、PMA、SC-3088、LPS+PMA、...
et al. Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Acta Pharmacol Sin 32, 1475–1482 (2011). https://doi.org/10.1038/aps.2011.120 Download citation Received08 January 2011 Accepted25 July 2011 Published10 October ...
6) Signalling pathway 信号通路 1. The mammalian target of rapamycin, mTOR, is a serine/threonine protein kinase that plays a crucial role in the nutrient-sensitive signalling pathway and the regulation of cell growth and proliferation. PI3K/Akt和Akt/TSC1-TSC2两条信号通路都可调控mTOR活性,...
Acta Pharmacol Sin 2011; 32: 1475-82.Wogonin ameliorates lipotoxicity-induced apoptosis of cultured vascular smooth muscle cells via interfering with DAG-PKC pathway. Yu-min LIU,Xiong WANG,Ahmed NAWAZ,Zhao-hong KONG,Yan HONG,Chang-hua WANG,Jun-jian ZHANG. Acta Pharmacological Sinica . 2011...
The induction of CXCR4 expression in human osteoblast-like cells (MG63) by CoCr particles is regulated by the PLC-DAG-PKC pathwaydoi:10.1002/jbm.b.33770Osteolysis which leads to aseptic loosening of implants is a fundamental problem in joint replacement surgery (arthroplasty) and the leading ...