While the "Kennedy pathway" is the main pathway in mammalian cells, in bacteria and lower eukaryotes the precursor CDP-DAG is used in the de novo pathway by CDP-DAG alcohol O-phosphatidyl transferases to synthetize the basic lipids. Here we present the high-resolution structures of phosphatidyl...
1 The plant glycerolipid metabolic pathway related to cytidinediphosphate-diacylglycerol synthase 1 (CDS1). Rice RBL1 is homologous to yeast Cds1. CDP-DAG, cytidinediphosphate-diacylglycerol; DAG, diacylglycerol; PA, phosphatidic acid; PAH, phosphatidic acid phosphohydrolase; PC, phosphatidylcholine; ...