的daf一2,daf一16这两个作用于遗传调控通路下游的 基因进行介绍"]. 1daf-2基因D】 daf一2是胰岛素受体样基因,在线虫内它能调控 长寿和滞育.通过用PCRRFIP技术,Kimura等报 道daf一2基因的最小尺度是33kb.其cDNA包括一 个120个碱基的5端非翻译区(UTR),一个5538 ...
(1994). daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans. Genetics 137(1), 107-120.Gottlieb S, Ruvkun G (1994) daf-2, daf-16 and daf-23: genetically interacting genes controlling dauer formation in Caenorhabditis elegans. Genetics ...
结果 与空白组比较,梓醇未延长突变体线虫daf-2和daf-16的寿命,对生殖能力无影响,未改善衰老引起的运动能力下降,未明显提高紫外辐射、高温、胡桃醌和过氧化氢应激条件下的生存时长(均P>0.05);对于胰岛素信号通路上衰老相关基因检测结果表明,daf-2突变体线虫体内daf-16 mRNA表达水平无显著差异(P>0.05),其下游靶基因...
摘要: 在长寿和衰老的研究中,人们发现调控休眠态的幼虫形成的基因(daf基因)能影响线虫的长寿.其中daf-2、daf-16是作用于这一遗传调控通路下游的两个重要基因.daf-2是胰岛素受体样基因,daf-16是编码转录调控因子中叉头家族/肝细胞核心因子3(HNF-3)的成员.关键词:...
intestine-specific loss of DAF-2 activates DAF-16 in and outside the intestine, causes almost no adverse effects on development and reproduction, and extends lifespan by 94% in a way that partly requires non-intestinal DAF-16. Consistent with intestine supplying nutrients to the entire body, ...
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CAM16 Jsh lightness: 84.931, saturation: 26.921, hue: 306.329 CAM16 QCh perceived brightness: 181.58, chroma: 15.049, hue: 306.329 CAM16 QMh perceived brightness: 181.58, colorfulness: 13.16, hue: 306.329 CAM16 Qsh perceived brightness: 181.58, saturation: 26.921, hue: 306.329 CAM16 UCS JMh ...
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Conversely, we examined whether DAF-16 activity was changed upon inhibition of smg-2. Unexpectedly, we found that smg-2 RNAi increased the nuclear localization of DAF-16::GFP in WT and daf-2(e1368), a weak daf-2 mutant allele amenable for the detection of an increase in nuclear DAF-16...
秀丽隐杆线虫中与衰老相关的DAF_2_IGF_1信号通路研究进展_毛玉琴