The daf-2 Gene Acts in the Adult to Limit Life SpanPl, LarsenDl, Riddle
1994. daf-2, daf-16, and daf-23: Genetically interacting ... S Gottlieb,G Ruvkun - 《Genetics》 被引量: 0发表: 1994年 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans Longevity is regulated by the...
The main source of the confusion is that the exact expression pattern ofdaf-2is unclear. Thedaf-2gene is 50 kb long, with large introns, multiple transcription start sites and alternative splicing sites; there are also multiple, long cDNAs. These characteristics make it difficult to reliably ...
的daf一2,daf一16这两个作用于遗传调控通路下游的 基因进行介绍"]. 1daf-2基因D】 daf一2是胰岛素受体样基因,在线虫内它能调控 长寿和滞育.通过用PCRRFIP技术,Kimura等报 道daf一2基因的最小尺度是33kb.其cDNA包括一 个120个碱基的5端非翻译区(UTR),一个5538 ...
其中 daf一2、daf一16是作用于这一遗传调控通路下游的两个重要基因。daf一2是胰岛素受体样基因,daf一16是编码转录调 控因子中叉头家族/肝细胞核心因子3(HNF一3)的成员。 关键词长寿,衰老,daf一2.daf一16 当环境条件适合生长繁殖时,线虫(C.elegans) 的胚胎后期发育经过4个阶段发育成成虫。然而, 道daf一2...
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gene expression. Fluorescence microscopyrevealed that fluorescence enhancement was detected after interference of mpk- 1 gene expression in C. elegans with expressionof lipogenic enzymes fat- 7∷ gfp, and intranuclear transference of DAF- 16 was promoted after interference of mpk- 1 geneexpression in ...
In this study, a Bxdaf‐16‐2b gene encoding 510 amino acids was cloned from Bursaphelenchus xylophilus . Sequence analysis showed that the BxDAF‐16‐2b protein shared the highest similarity value (92%) with the DAF16‐2 (accession no. ADD84716.1 ) of B. xylophilus . Using in situ ...
aShe then found a second gene, Daf-16, that plays the opposite role. Turning it up increased youthfulness in the worms. Both mutations were needed for longevity to occur in the worms.[translate]
The daf-2 gene-product exerts its effects by influencing downstream signalling, in particular via the actions of another gene belonging to the dauer-formation gene family, daf-16, which daf-2 inhibits [15]. Mutations in daf-16 reduce the lifespan of daf-2 mutants back to that of wild typ...