drug discoverymirror imagenative chemical ligationp53phage displayDespite a sharp increase in the expenditures for drug research and development (R&D) in the past decade, the declining trend in the number of new drugs approved annually by the US Food and Drug Administration continues. This growing ...
ArticleCAS Chen, Y. & Liu, L. Modern methods for delivery of drugs across the blood–brain barrier.Adv Drug Deliv Rev64, 640–665 (2012). Pardridge, W. M. Drug and gene targeting to the brain with molecular trojan horses.Nat Rev Drug Discov1, 131–139 (2002). ArticleCASPubMedGoogle...
Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxyto...
Journal of Medicinal Chemistry - Peptide-Based Drug Design: Controlling Transport and Metabolism Editors: Michael D. Taylor and Gordon L. Amidon. American Chemical Society, Washington, D.C. 1995. xviii + 567 pp. 18.5 × 26 cm. ISBN 0-841... Pottorf,S Richard - 《Journal of Medicinal Che...
Self-assembled peptide-lanthanide nanoclusters for safe tumor therapy: overcoming and utilizing biological barriers to peptide drug delivery. ACS Nano 12, 2017–2026 (2018). Article CAS PubMed Google Scholar Yan, J. et al. Carnosic acid-induced co-self-assembly of metal-peptide complexes into ...
The prehairpin intermediate represents a unique drug target with which to inhibit HIV entry, exposing the N-trimer and its hydrophobic grooves before the Cpeptideregion can fold back into these grooves and drive membrane fusion. Our lab has been developing entry inhibitors composed of D-peptides ...
点击上方的 行舟Drug ▲ 添加关注 我们先来说一个旧闻,就是据说中国距离诺贝尔化学奖最近的一次——结晶牛胰岛素的合成。 现代科学研究表明人的血糖浓度应该被控制在4到7毫摩。进餐后血糖升高,空腹时血糖降低,但都会被激素调控在这个范围之内。过多的...
A d-peptide ligand of the nicotine acetylcholine receptors (nAChRs), termed DCDX, enables drug delivery to the brain when incorporated into liposomes and has shown promise as a nanocarrier for treating brain diseases. However, few reports have described the mechanisms whereby DCDX-modified liposomes...
展开 关键词: Peptides Drug Evaluation, Preclinical Drug Delivery Systems Sequence Analysis, Protein Protein Interaction Mapping Biodiversity Protein Binding Drug Design Binding Sites Peptide Library DOI: 10.1038/nbt1190 被引量: 226 年份: 2006 收藏 引用 批量引用 报错 分享 全部...
Advances in peptide synthesis and peptide functional screening methods in the last decades have brought about a renaissance in peptide drug discovery [1]. The potential of peptides and peptide-based compounds as diagnostic, theragnostic and therapeutic tools is increasingly recognized in academia and in...