Accumulation of the oncometabolite D-2-hydroxyglutaric acid (2HG) and its release into the blood is associated with dilated cardiomyopathy. The mechanisms leading to changes in cardiac metabolism and contractile function are unknown. We studied in the isolated working rat heart preparation metabolic ...
Even though children with D-2-HGA often suffer epileptic attacks, every new (transient) neurological deficit should be followed up by an MRI/MRA so as not to oversee a possible underlying MMS. After diagnosis, EDAMS in combination with acetylsalicylic acid (ASA) is recommended to prevent furth...
储存方式:4°C,密封储存 D-α-Hydroxyglutaric acid 是α-酮戊二酸 (α-KG) 的弱竞争拮抗剂,可抑制多种 α-KG 依赖性双加氧酶 (dioxygenases),Ki 为 10.87 mM。D-α-Hydroxyglutaric acid 可增加活性氧 (ROS) 的产生。D-α-Hydroxyglutaric acid 还可结合并抑制 ATP 合酶并抑制 mTOR 信号传导。 结构式...
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英文名称D-α-Hydroxyglutaric acid disodium salt 生化机理突变的异柠檬酸脱氢酶1(IDH1)和IDH2产生的oncometabolite。在鼠胚胎成纤维细胞中抑制KDM4A,从而激活mTOR。还激活骨髓基质细胞中的NF-κB并抑制FTO(mRNA N6-甲基腺嘌呤脱甲基酶)。 应用An α hydroxy acid ...
伪-Hydroxynonanoic acid S-2-羟基戊酸 S-2-羟基丁酸 R-2-羟基戊二酸 4-乙基-3-己醇 3-乙基-2-甲基-1-戊烯 最新化合物 2512227-07-3 2514876-88-9 2857862-12-3 309245-16-7 351999-18-3 72601-97-9 76021-78-8 309244-90-4 400628-17-3 938193-98-7 92000-72-1 309247-50-5 348079-18-...
基本描述 别名(R)-2-羟基戊二酸 | (R)-2-羟基戊二酸二钠 规格或纯度10mM in Water 英文名称D-α-Hydroxyglutaric acid disodium salt 生化机理突变的异柠檬酸脱氢酶1(IDH1)和IDH2产生的oncometabolite。在鼠胚胎成纤维细胞中抑制KDM4A,从而激活mTOR。还激活骨髓基质细胞中的NF-κB并抑制FTO(mRNA N6-甲基腺嘌...