STK31 contains a putative D-box motif.PaoLin KuoYungLing HuangChristine ChinJung HsiehJenqChang LeeBoWen LinLiangYi Hung
a well-established D-box motif found in the promoter region of thePer2gene3. TGATGTAA (D-box#3), TTATGTCA (D-box#4), and TTGTGTAA (D-box#5) are two-mismatched sequences of D-box#1 or alternatively are considered one-mismatched sequences of D-box#2. TTATACAA (D-box#6) is...
D-BOX signs deal with Link DC China LONGUEUIL, Que. - D-BOX Technologies Inc., a Quebe J Terrett - 《Plant Advancing Canadian Manufacturing》 被引量: 0发表: 2016年 STK31 contains a putative D-box motif. LONGUEUIL, Que. - D-BOX Technologies Inc., a Quebe PL Kuo,YL Huang,CJ Hsieh...
Moreover, we show that this degradation sequence acts as a transposable motif and induces the proteolysis of a GST-GXEN fusion protein. Finally, we demonstrate that both a D-box and a GXEN-containing peptides completely block APC-dependent degradation of cyclin B and Xkid, indicating that ...
a, A schematic illustration of PD-L1 with N-terminal signal peptide, extracellular domain, transmembrane domain, cytoplasmic tail and the potential SPOP-binding motif in PD-L1. b, d, Immunoblot analysis of WCL and glutathione S-transferase (GST) pull-down precipitates derived from 293T cells tr...
图3 Design of the genomic knock-in assay to measure the level of gene-editing efficiency. FL, fluorescent; PAM, protospacer adjacent motif. 在精确敲入后,作者测量了荧光蛋白表达细胞的百分比,以量化基因编辑效率(图4)。作者的测试表明,相对于人类细胞中的其他SSAP,RecT具有更高的编辑活性,而没有编辑仅用...
在正常血钙浓度下(9.5mg/dl),肾脏组织中1α羟基化酶与24羟基化酶均具有活性,因此既能够合成1,25(OH) 2 D,也能够合成24,25(OH) 2 D,活性维生素D的产生和降解达到平衡,而血清钙浓度降低时,刺激1α羟基化酶的活性增加,而当血清钙浓度较高时明显抑制此酶活性,由此可以调节1,25(OH) 2 D的合成量。1,25(...
D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p We demonstrate that Hsl1p contains both a destruction box (D box) and a KEN box motif that are necessary for Hsl1p turnover with either APCor APC... Burton...
motif最先是通过实验的方法发现的,换句话说,不是说有了ChIP-seq才有了motif分析,起始很早人们就开始研究motif了!例如,'TATAAT’ box在1975年就被pribnow发现了,它与上游的‘TTGACA’motif是RNA聚合酶结合位点的特异性序列。而且,当时的人们就知道,不是所有的结合位点都一定完美地与motif匹配,大部分都只匹配了12个...
在正常血钙浓度下(9.5mg/dl),肾脏组织中1α羟基化酶与24羟基化酶均具有活性,因此既能够合成1,25(OH) 2 D,也能够合成24,25(OH) 2 D,活性维生素D的产生和降解达到平衡,而血清钙浓度降低时,刺激1α羟基化酶的活性增加,而当血清钙浓度较高时明显抑制此酶活性,由此可以调节1,25(OH) 2 D的合成量。1,25(...