The conventional recognition model of the TATA-box in DNA sequence analysis is based on the use of a position weight matrix (PWM). The PWM model of the TATA-box is widely used in promoter recognition programs. This chapter presents a different, nonlinear, recognition model of this motif, ...
Here, we remark that miRNA-mediated transcriptional modulation, through the TATA-box motif, may be a synergistic approach for transcriptional control. 展开 关键词: AGO proteins chromatin miRNAs TATA-box motif transcriptional gene regulation DOI: 10.1515/bmc-2015-0004 ...
The TATA box is a core promoter motif that is recognized and bound by the TBP subunit of the TFIID complex. It is present in a subset of mammalian core promoters and is conserved across different species from archaebacteria to humans. ...
Transcription of the human tissue-type plasminogen activator (tPA) gene has been reported to initiate from a single site proximal to a TATA box motif [1985, J. Biol. Chem. 260, 11223-11230]. In this study, we utilized primer extension analysis to evaluate the tPA mRNA start site in ...
The C allele, which eliminates TATA box motif, was detected in 11 breeds and its value frequency ranged from 0.006 (Thoroughbred) to 0.400 (Norico). The homozygous C/C genotype was detected in Haflinger, Bardigiano, Norico and Tolfetano breeds. The presence of the polymorphism within a ...
Human transcription factor TFIID, the TATA-binding protein, was partially purified to a form capable of associating stably with the TATA motif of the adenovirus major late promoter. Binding of the human and yeast TFIID to the TATA motif ... E Maldonado,I Ha,P Cortes,... - 《Molecular & ...
专业医学词典 TATA区:同Hogness box,TATA框,戈德堡-霍格内斯框 与"TATA box"相近的词条 ...
Similarly, transcripts initiating upstream of CAGT (distal transcripts) were eliminated by mutations in the distal TATA but were unaffected by substitutions in the proximal TATA box. Proximal transcripts were not detected with a plasmid containing mutations in the CAGT motif, although the distal ...
In addition, one truncation mutation (Tyr374STOP) has been found in a male sporadic patient67 and one mutation in the first RNA recognition motif (RRM1) has been described in a female sporadic case.65 The A90V variant in the middle of the bipartite nuclear localizing sequence has been ...
complex. In addition to theTATA box, other major CPEs recognized by TFIID orTAFsinclude the initiator (INR),downstream promoter element(DPE), and motif ten element (MTE;Juven-Gershon et al., 2008). The sequence immediately flanking the TATA box can contain TFIIB recognition elements (BREs). ...